{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:07:22Z","timestamp":1787062042341,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM103643"],"award-info":[{"award-number":["P20GM103643"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["1R15HD091841"],"award-info":[{"award-number":["1R15HD091841"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Early life trauma has been linked to increased risks for anxiety, depression, and chronic pain. We used rodent models of acute and inflammatory neonatal pain to explore effects on fear conditioning and somatosensory function. Hindpaw needle pricks or handling on postnatal days (PNDs) 1\u20137 caused lasting impacts on affective and somatosensory function when assessed at later ages, PNDs 24 (postweaning), 45 (adolescence), or 66 (adulthood). First, auditory, but not contextual, freezing was mildly disrupted regardless of age. Second, a profound postfear conditioning tactile hypersensitivity was observed in neonatally stressed, postweaning rats. In the absence of fear conditioning, the mechanical hypersensitivity was not observed, consistent with a two\u2010hit model of psychopathology. Injections of 2% \u03b1\u2010carrageenan did not have the same lasting impact but was slightly protective against observed effects of neonatal vehicle injections. Basal and elicited corticosterone levels postweaning were not altered by neonatal pain or handling. These data demonstrate that neonatal adversity can have lasting impacts on affective and somatosensory function that differs regardless of age.<\/jats:p>","DOI":"10.1002\/dev.21632","type":"journal-article","created":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T22:39:38Z","timestamp":1525991978000},"page":"520-533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Neonatal pain and stress disrupts later\u2010life pavlovian fear conditioning and sensory function in rats: Evidence for a two\u2010hit model"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1496-2123","authenticated-orcid":false,"given":"Seth M.","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Psychology University of New England Biddeford Maine"},{"name":"Department of Biomedical Sciences University of New England Biddeford Maine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makaela","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of Psychology University of New England Biddeford Maine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Rudlong","sequence":"additional","affiliation":[{"name":"Department of Psychology University of New England Biddeford Maine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Eaton","sequence":"additional","affiliation":[{"name":"Department of Psychology University of New England Biddeford Maine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"King","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of New England Biddeford Maine"},{"name":"Center for Excellence in the Neurosciences University of New England Biddeford Maine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2308-8570","authenticated-orcid":false,"given":"Michael A.","family":"Burman","sequence":"additional","affiliation":[{"name":"Department of Psychology University of New England Biddeford Maine"},{"name":"Department of Biomedical Sciences University of New England Biddeford Maine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13442"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0620C"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(98)00338-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674371506000404"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr288"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(01)00432-2"},{"issue":"26","key":"e_1_2_7_8_1","first-page":"1","article-title":"A simplified up\u2010down method (SUDO) for measuring mechanical nociception in rodents using von Frey filaments","volume":"10","author":"Bonin R. 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