{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:27:50Z","timestamp":1775593670716,"version":"3.50.1"},"reference-count":105,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Behavioral and Social Sciences Dean\u2019s Research Initiative"},{"name":"University of Maryland College of Behavioral and Social Sciences Dean\u2019s MRI Research Initiative RFP Program"},{"name":"Research and Scholarship Award"},{"name":"Maryland Neuroimaging Center Seed Grant Program"},{"name":"National Science Foundation in partnership with the University of Maryland"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Rodent models indicate that parenting shapes offspring outcomes by programming the hypothalamic\u2013pituitary\u2013adrenal axis response to stress and, ultimately, altering brain structure and function. The present study tested this hypothesis and explored possible timing\u2010dependent associations in a longitudinal sample of children (\n                    <jats:italic>N\u00a0=\u00a0<\/jats:italic>\n                    63). At Time 1 (\n                    <jats:italic>M\u00a0=\u00a0<\/jats:italic>\n                    4.23\u00a0\u00b1\u00a00.84\u00a0years) and Time 2 (\n                    <jats:italic>M\u00a0=\u00a0<\/jats:italic>\n                    7.20\u00a0\u00b1\u00a00.89\u00a0years), children completed parent\u2013child interaction tasks and a laboratory stressor after which salivary cortisol samples were collected. At Time 2, children also completed a structural MRI. Analyses revealed timing\u2010 and region\u2010dependent associations between early and concurrent parenting and cortisol reactivity and hippocampal subregion volumes. Moreover, greater negative parenting during early childhood predicted greater cortisol reactivity three years later, which, in turn, led to reduced left hippocampal tail volume. Findings suggest that the hippocampus is sensitive to environmental influences during early childhood, a result that parallels findings from rodent models.\n                  <\/jats:p>","DOI":"10.1002\/dev.21788","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T23:04:24Z","timestamp":1538780664000},"page":"125-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Early parenting predicts hippocampal subregion volume via stress reactivity in childhood"],"prefix":"10.1002","volume":"61","author":[{"given":"Sarah L.","family":"Blankenship","sequence":"first","affiliation":[{"name":"Department of Psychology University of Maryland College Park Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Chad\u2010Friedman","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Maryland College Park Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Riggins","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Maryland College Park Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2612-7686","authenticated-orcid":false,"given":"Lea R.","family":"Dougherty","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Maryland College Park Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.06.011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2008.20.3.292"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.06.022"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2010.02281.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23353"},{"key":"e_1_2_7_7_1","volume-title":"Parenting and the child\u2019s world: Influences on academic, intellectual, and social\u2010emotional development","author":"Borkowski J. G.","year":"2002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0018-506X(02)00008-9"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10578-013-0371-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199707000-00012"},{"issue":"6","key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1139\/jpn.0441","article-title":"The role of the hippocampus in the pathophysiology of major depression","volume":"29","author":"Campbell S.","year":"2004","journal-title":"Journal of Psychiatry & Neuroscience"},{"key":"e_1_2_7_12_1","volume-title":"Handbook of attachment: Theory, Research, and Clinical Applications","author":"Cassidy J.","year":"2016"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0526-08.2008"},{"issue":"6","key":"e_1_2_7_14_1","first-page":"395","article-title":"Chronic Stress\u2010Induced Hippocampal Vulnerability: The Glucocorticoid Vulnerability Hypothesis","volume":"19","author":"Conrad C. D.","year":"2009","journal-title":"Reviews in the Neurosciences"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft221"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.07.025"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht160"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.130.3.355"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956797611404084"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10802-013-9763-7"},{"key":"e_1_2_7_21_1","unstructured":"Egeland B. Weinfield N. Hiester M. Lawrence C. Pierce S. &Chippendale K.(1995).Teaching tasks administration and scoring manual."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2008.12.011"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.100022"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.1998.0293"},{"key":"e_1_2_7_25_1","volume-title":"Discovering Statistics Using SPSS","author":"Field A.","year":"2009"},{"key":"e_1_2_7_26_1","volume-title":"Structured Clinical Interview for DSM\u2010IV Axis I Disorders: Non\u2010patient edition (Version 2.)","author":"First M. B.","year":"1996"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2009.01380.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2005.04.006"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.03.012"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.8"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960304)366:2<223::AID-CNE3>3.0.CO;2-7"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.10.008"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/17470919.2015.1070747"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.02.010"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956797610385357"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/03637750903310360"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.02.032"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-12-2-118"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.01.025"},{"key":"e_1_2_7_40_1","article-title":"Early childhood cortisol reactivity moderates the effects of parent\u2010child relationship quality on the development of children\u2019s temperament in early childhood","author":"Kopala\u2010Sibley D. C.","year":"2015","journal-title":"Developmental Science"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12784"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2011.02.003"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890902874913"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21166"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2018.16.1.46"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21435"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jst048"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000101"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5332.1659"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118003109"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601443113"},{"key":"e_1_2_7_52_1","first-page":"49","volume-title":"Proceedings National Institute of Science, India","author":"Mahalanobis P. C.","year":"1936"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.09.042"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2011.12.013"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121254109"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.10.012"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2009.02084.x"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439225"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21354"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2012.00307"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.327"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.01.017"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2009-2"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.04.013"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.03.005"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.10.014"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.3758\/BRM.40.3.879"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(02)00108-7"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2006.12.007"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.07.003"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi044"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.133"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/cdev.12445"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2013.10.002"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470316696"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(87)90065-8"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)90180-1"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-09-02897.1990"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_01028"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.08.013"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2014.09.001"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.7.4.422"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291797005242"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00153"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20097"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21079"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(03)00007-1"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115396109"},{"key":"e_1_2_7_89_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/neuro.09.055.2009","article-title":"BDNF genotype modulates resting functional connectivity in children","volume":"3","author":"Thomason M. E.","year":"2009","journal-title":"Frontiers in Human Neuroscience"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10862-014-9410-9"},{"key":"e_1_2_7_91_1","first-page":"68","article-title":"A review of adversity, the amygdala and the hippocampus: A consideration of developmental timing","volume":"3","author":"Tottenham N.","year":"2009","journal-title":"Frontiers in Human Neuroscience"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1063(1998)8:3<198::AID-HIPO2>3.0.CO;2-G"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046970"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.1994.1030"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20492"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46429"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.9.1743"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2004.05.018"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2013.10.006"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147774"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.02.011"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.03.072"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.030"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22125"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2016.10.003"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10578-012-0304-3"}],"container-title":["Developmental Psychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdev.21788","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dev.21788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T18:41:47Z","timestamp":1775241707000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dev.21788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,4]]},"references-count":105,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/dev.21788"],"URL":"https:\/\/doi.org\/10.1002\/dev.21788","archive":["Portico"],"relation":{},"ISSN":["0012-1630","1098-2302"],"issn-type":[{"value":"0012-1630","type":"print"},{"value":"1098-2302","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,4]]},"assertion":[{"value":"2018-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}