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The current study examined hair cortisol concentration (HCC) during the third trimester of pregnancy as a mediator between maternal adversity indicators (childhood abuse, severe mental illness, symptomatic functioning) and maternal caregiving behavior at 4\u00a0months postpartum. Forty\u2010four women participated in the study: 30 with severe mental disorders, and 14 nonclinical controls. HCC was assessed during the third trimester of pregnancy (HCC\u2010P) and at 4\u00a0months postpartum (HCC\u20104M). Sexual, physical, and emotional abuse were assessed by the Adverse Childhood Experiences Study Questionnaire. Maternal disrupted interaction was reliably coded from mother\u2013infant video interactions during a Still\u2010Face Procedure. Mediation models indicated that maternal HCC\u2010P and HCC\u20104M mediated associations between maternal psychopathology (severe mental illness, symptomatic functioning) and maternal disrupted interaction at 4\u00a0months. Maternal HCC at 4\u00a0months also mediated associations between experienced childhood abuse and overall disrupted interaction. Our findings indicate that HCC may be a potential early biomarker for future caregiving challenges among mothers with severe mental illness and histories of childhood abuse.<\/jats:p>","DOI":"10.1002\/dev.21833","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T11:22:52Z","timestamp":1549970572000},"page":"543-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Hair cortisol in the perinatal period mediates associations between maternal adversity and disrupted maternal interaction in early infancy"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0504-303X","authenticated-orcid":false,"given":"Maja","family":"Nystr\u00f6m\u2010Hansen","sequence":"first","affiliation":[{"name":"Department of Psychology University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4603-9504","authenticated-orcid":false,"given":"Marianne S.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6703-4198","authenticated-orcid":false,"given":"Jennifer E.","family":"Khoury","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Harvard Medical School, Cambridge Hospital Cambridge"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3262-6097","authenticated-orcid":false,"given":"Kirstine","family":"Davidsen","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Mental Health Odense, Research Unit Mental Health Services in the Region of Southern Denmark Odense Denmark"},{"name":"Department of Psychology University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8888-938X","authenticated-orcid":false,"given":"Andrew","family":"Gumley","sequence":"additional","affiliation":[{"name":"Institute of Health and Wellbeing University of Glasgow Glasgow, Scotland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9799-976X","authenticated-orcid":false,"given":"Karlen","family":"Lyons\u2010Ruth","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Harvard Medical School, Cambridge Hospital Cambridge"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0618-044X","authenticated-orcid":false,"given":"Angus","family":"MacBeth","sequence":"additional","affiliation":[{"name":"School of Health in Social Science University of Edinburgh Edinburgh, Scotland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2074-9097","authenticated-orcid":false,"given":"Susanne","family":"Harder","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.02.041"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2010.02306.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.12.025"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/infa.12015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2009.214"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.10.005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(98)00017-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2006.06.008"},{"key":"e_1_2_10_11_1","volume-title":"Structured clinical interview for DSM\u20105 disorders \u2013 clinical version (SCID\u20105\u2010CV)","author":"First M. 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