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This study examined whether maternal anxiety, depression, and stress during pregnancy is associated with the diversity of meconium microbiome, the first internal discharge, in 75 newborns from an existing birth cohort study. The meconium microbiome was profiled using multibarcode16S rRNA sequencing at V3\u2010V4 hypervariable region followed by taxonomic assignment to the green gene 16S references at 97% similarity and diversity analysis at the genus level. Results showed that the meconium contained diversified microbiota, and greater pregnancy\u2010related anxiety was significantly associated with a less diverse meconium microbiota community (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). At the specific taxa level, greater pregnancy\u2010related anxiety was correlated with a lower level of the <jats:italic>Enterococcaceae<\/jats:italic> family (<jats:italic>p<\/jats:italic>\u00a0=\u00a02e\u20104, Spearman rho\u00a0=\u00a0\u22120.43). These findings support a significant role of prenatal maternal mood in the early\u2010life bacteria colonization of their offspring.<\/jats:p>","DOI":"10.1002\/dev.21837","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T18:57:11Z","timestamp":1553540231000},"page":"640-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Microbiota of newborn meconium is associated with maternal anxiety experienced during pregnancy"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8546-5111","authenticated-orcid":false,"given":"Jianzhong","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Ly","sequence":"additional","affiliation":[{"name":"Department of Psychology Queens 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