{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T08:07:48Z","timestamp":1771920468241,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM103643"],"award-info":[{"award-number":["P20GM103643"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R15HD091841"],"award-info":[{"award-number":["R15HD091841"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infants spending extended time in the neonatal intensive care unit are at greater risk of developing a variety of mental health problems later in life, possibly due to exposure to painful\/stressful events. We used a rodent model of inflammatory neonatal pain to explore effects on fear conditioning, somatosensory function and maternal behavior. Hindpaw injections of 2% \u03bb\u2010carrageenan on postnatal days 1 and 4 produced an attenuation in conditioned freezing during the postweaning period, similar to our previous work with acute pain, but did not cause lasting impacts on contextual freezing nor somatosensory function. Additionally, we assessed maternal behavior to observe dam\u2013pup interactions during the neonatal period. Results showed dams of litters which experienced pain spent similar amounts of time with pups as undisturbed controls. However, the specific behaviors differed per condition. Dams of pain litters exhibited less time licking\/grooming, but more time nursing than controls. These results suggest changes in maternal care following pain could be a contributing factor underlying the long\u2010term effects of neonatal trauma. Furthermore, our laboratory has previously shown acute, but not inflammatory pain, disrupted conditioned freezing; the current experiment observed the long\u2010term effects of neonatal inflammatory pain on conditioned fear using a weak conditioning protocol.<\/jats:p>","DOI":"10.1002\/dev.21889","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T02:34:53Z","timestamp":1562207693000},"page":"88-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Inflammatory neonatal pain disrupts maternal behavior and subsequent fear conditioning in a rodent model"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1496-2123","authenticated-orcid":false,"given":"Seth M.","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Psychology University of New England Biddeford Maine"},{"name":"Center for Excellence in the Neurosciences University of New England Biddeford Maine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makaela","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of Psychology University of New England Biddeford Maine"},{"name":"Center for Excellence in the Neurosciences University of New England Biddeford Maine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2308-8570","authenticated-orcid":false,"given":"Michael A.","family":"Burman","sequence":"additional","affiliation":[{"name":"Department of Psychology University of New England Biddeford Maine"},{"name":"Center for Excellence in the Neurosciences University of New England Biddeford Maine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(98)00338-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000014197"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.11.039"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.02.031"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21135"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.72.1.F47"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(01)00432-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.109.2.342"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22267"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2013.11.005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.9.5335"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnv117"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0526-08.2008"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"issue":"7","key":"e_1_2_8_16_1","first-page":"736","article-title":"Neonatal pain and stress disrupts later\u2010life pavlovian fear conditioning and sensory function in rats: Evidence for a two\u2010hit model","volume":"105","author":"Davis S. 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