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Individuals with PTSD are more likely to develop alcohol and substance abuse related disorders. We assessed if prenatal and early postnatal alcohol exposure (PAE) increased the susceptibility to retain aversive memories and if this was associated with subsequent heightened alcohol consumption. Pregnant Sprague\u2010Dawley rats were exposed for 22\u00a0hr\/day, throughout pregnancy and until postnatal Day 7 to a single bottle of sucralose \u2010 sweetened 10% alcohol solution (PAE Group), or to a single bottle of tap water and sucralose (Control Group). Auditory fear conditioning (AFC) was performed in the adolescent offspring at postnatal Day 40. Freezing was measured during acquisition, retention and extinction phases, followed by 3\u00a0weeks of free choice alcohol intake. Female, but not male, PAE rats exhibited impaired extinction of the aversive memory, a finding associated with higher levels of 3\u20104 Dihidroxyphenylacetic acid (DOPAC) in the nucleus accumbens and heightened alcohol intake, respect to controls. These findings suggest that PAE makes females more vulnerable to long\u2010term retention of aversive memories, which coexist with heightened alcohol intake. These findings are reminiscent of those of PTSD.<\/jats:p>","DOI":"10.1002\/dev.21925","type":"journal-article","created":{"date-parts":[[2019,9,29]],"date-time":"2019-09-29T01:09:29Z","timestamp":1569719369000},"page":"519-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pre\u2010 and postnatal alcohol exposure delays, in female but not in male rats, the extinction of an auditory fear conditioned memory and increases alcohol consumption"],"prefix":"10.1002","volume":"62","author":[{"given":"Wladimir","family":"Plaza","sequence":"first","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas Facultad de Medicina Universidad Cat\u00f3lica del Norte Coquimbo Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Gaschino","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas Facultad de Medicina Universidad Cat\u00f3lica del Norte Coquimbo Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas Facultad de Medicina Universidad Cat\u00f3lica del Norte Coquimbo Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Santiba\u00f1ez","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas Facultad de Medicina Universidad Cat\u00f3lica del Norte Coquimbo Chile"},{"name":"Programa de Mag\u00edster en Ciencias Biol\u00f3gicas menci\u00f3n Neurociencia Facultad de Ciencias Universidad de Valpara\u00edso Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Estay\u2010Olmos","sequence":"additional","affiliation":[{"name":"Centro de Neurobiolog\u00eda y Fisiopatolog\u00eda Integrativa Instituto de Fisiolog\u00eda Facultad de Ciencias Universidad de Valpara\u00edso Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Sotomayor\u2010Z\u00e1rate","sequence":"additional","affiliation":[{"name":"Centro de Neurobiolog\u00eda y Fisiopatolog\u00eda Integrativa Instituto de Fisiolog\u00eda Facultad de Ciencias Universidad de Valpara\u00edso Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"De la Fuente\u2010Ortega","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas Facultad de Medicina Universidad Cat\u00f3lica del Norte Coquimbo Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1876-2321","authenticated-orcid":false,"given":"Ricardo M.","family":"Pautassi","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n M\u00e9dica M. y M. 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