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A limited number of studies have investigated age difference in relapse following re\u2010exposure to the drug after a period of abstinence. Using a cocaine self\u2010administration paradigm, we showed no age difference in acquisition or extinction of self\u2010administration. Interestingly, adolescent rats displayed impaired cocaine\u2010primed reinstatement of cocaine seeking. Using the same dose as that self\u2010administered in the first experiment, we then investigated age differences in acquisition and extinction of conditioned place preference, as well as locomotor sensitization. While there were no differences in locomotor activity or acquisition of preference, adolescents failed to extinguish their preference, even when the number of extinction sessions was doubled from what adults received. Taken together, these results suggest that while cocaine has similar rewarding and reinforcing effects regardless of age, adolescents may attribute stronger salience to the drug\u2010associated context. In addition, re\u2010exposure to cocaine itself may not be a strong relapse trigger in adolescence. Overall, these findings suggest that we should focus more on alleviating drug\u2010context salience compared to re\u2010exposure to substance in order to reduce relapse of drug seeking in adolescents.<\/jats:p>","DOI":"10.1002\/dev.22017","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T08:05:04Z","timestamp":1594800304000},"page":"125-137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Extinction and drug\u2010induced reinstatement of cocaine seeking following self\u2010administration or conditioned place preference in adolescent and adult rats"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3833-3620","authenticated-orcid":false,"given":"Alexandre A.","family":"Guerin","sequence":"first","affiliation":[{"name":"Mental Health Theme The Florey Institute of Neuroscience and Mental Health Parkville VIC Australia"},{"name":"Florey Department of Neuroscience and Mental Health University of Melbourne Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6816-1199","authenticated-orcid":false,"given":"Isabel C.","family":"Zbukvic","sequence":"additional","affiliation":[{"name":"Mental Health Theme The Florey Institute of Neuroscience and Mental Health Parkville VIC Australia"},{"name":"Florey Department of Neuroscience and Mental Health University of Melbourne Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5058-3281","authenticated-orcid":false,"given":"Sophia J.","family":"Luikinga","sequence":"additional","affiliation":[{"name":"Mental Health Theme The Florey Institute of Neuroscience and Mental Health Parkville VIC Australia"},{"name":"Florey Department of Neuroscience and Mental Health University of Melbourne Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-7676","authenticated-orcid":false,"given":"Katherine D.","family":"Drummond","sequence":"additional","affiliation":[{"name":"Mental Health Theme The Florey Institute of Neuroscience and Mental Health Parkville VIC Australia"},{"name":"Florey Department of Neuroscience and Mental Health University of Melbourne Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Mental Health Theme The Florey Institute of Neuroscience and Mental Health Parkville VIC Australia"},{"name":"Florey Department of Neuroscience and Mental Health University of Melbourne Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather B.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Mental Health Theme The Florey Institute of Neuroscience and Mental Health Parkville VIC Australia"},{"name":"Florey Department of Neuroscience and Mental Health University of Melbourne Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1299-4300","authenticated-orcid":false,"given":"Jee Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Mental Health Theme The Florey Institute of Neuroscience and Mental Health Parkville VIC Australia"},{"name":"Florey Department of Neuroscience and Mental Health University of Melbourne Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300834"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-009-1721-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(95)01194-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.08.034"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00220"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.122.2.460"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5064-07.2008"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015889"},{"issue":"1","key":"e_1_2_6_10_1","first-page":"41","article-title":"Underage alcohol use: Summary of developmental processes and mechanisms: Ages 16\u201320","volume":"32","author":"Brown S. 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