{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:17:47Z","timestamp":1788913067519,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adverse childhood experiences (ACEs) heighten the risk for adult obesity and cardiometabolic disease, but physiological factors underlying this connection are not well understood. We determined if ACEs were associated with physiological stress response and insulin resistance in adolescents at risk for adult obesity. Participants were 90 adolescents 12.0\u201317.5 years (50% female, 30% Hispanic\/Latinx), at risk for adult obesity by virtue of above\u2010average body mass index (BMI; kg\/m<jats:sup>2<\/jats:sup> \u2265 70th percentile) or parental obesity (BMI \u2265 30 kg\/m<jats:sup>2<\/jats:sup>). ACEs were determined as presence (vs. absence) based upon the Schedule for Affective Disorders and Schizophrenia for School\u2010Aged Children. Physiological stress response was measured as heart rate\/blood pressure response to the Trier Social Stress Test. Homeostatic model assessment of insulin resistance was determined from fasting glucose\/insulin. Sixty\u2010one percent of adolescents reported positive ACE history. The presence of ACEs predicted greater heart rate (<jats:italic>p<\/jats:italic> &lt; .001) and diastolic blood pressure (<jats:italic>p<\/jats:italic> = .02) response to stress, controlling for age, sex, race\/ethnicity, puberty, and BMI standard score. Systolic blood pressure and insulin resistance did not differ by ACE history (<jats:italic>p<\/jats:italic>\u2010values &gt; .08). Findings suggest heightened sympathetic stress response in adolescence could be explanatory in how ACEs increase the risk for later cardiometabolic disease. Future studies should characterize ACEs in relationship to day\u2010to\u2010day variations in adolescents\u2019 stress physiology and glucose homeostasis.<\/jats:p>","DOI":"10.1002\/dev.22127","type":"journal-article","created":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T14:19:22Z","timestamp":1621088362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Associations of adverse childhood experiences with stress physiology and insulin resistance in adolescents at risk for adult obesity"],"prefix":"10.1002","volume":"63","author":[{"given":"Virginia","family":"Jimenez","sequence":"first","affiliation":[{"name":"Department of Human Development and Family Studies Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Human Development and Family Studies Colorado State University  Fort Collins Colorado USA"},{"name":"Colorado School of Public Health  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L. M.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Human Development and Family Studies Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reagan L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Human Development and Family Studies Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Casamassima","sequence":"additional","affiliation":[{"name":"Department of Human Development and Family Studies Colorado State University  Fort Collins Colorado USA"},{"name":"Colorado School of Public Health  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Verros","sequence":"additional","affiliation":[{"name":"Department of Human Development and Family Studies Colorado State University  Fort Collins Colorado USA"},{"name":"Colorado School of Public Health  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Conte","sequence":"additional","affiliation":[{"name":"Department of Human Development and Family Studies Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metztli","family":"Ruiz\u2010Jaquez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Endocrinology University of Colorado Anschutz Medical Campus\/Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren D.","family":"Gulley","sequence":"additional","affiliation":[{"name":"Department of Human Development and Family Studies Colorado State University  Fort Collins Colorado USA"},{"name":"Department of Pediatrics, Section of Endocrinology University of Colorado Anschutz Medical Campus\/Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Food Science and Human Nutrition Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Melby","sequence":"additional","affiliation":[{"name":"Colorado School of Public Health  Aurora Colorado USA"},{"name":"Department of Food Science and Human Nutrition Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7558-2285","authenticated-orcid":false,"given":"Rachel G.","family":"Lucas\u2010Thompson","sequence":"additional","affiliation":[{"name":"Department of Human Development and Family Studies Colorado State University  Fort Collins Colorado USA"},{"name":"Colorado School of Public Health  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-8707","authenticated-orcid":false,"given":"Lauren B.","family":"Shomaker","sequence":"additional","affiliation":[{"name":"Department of Human Development and Family Studies Colorado State University  Fort Collins Colorado USA"},{"name":"Colorado School of Public Health  Aurora Colorado USA"},{"name":"Department of Pediatrics, Section of Endocrinology University of Colorado Anschutz Medical Campus\/Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003\u2010030722"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047\u20106310.2011.00046.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/1082\u2010989X.2.2.131"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.170021"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2009.06.021"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/dev0000596"},{"key":"e_1_2_8_8_1","volume-title":"National diabetes statistics report 2017","author":"Centers for Disease Control and Prevention","year":"2017"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25770"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2333794X18769555"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906\u2010014\u20100449\u20105"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0749\u20103797(98)00017\u20108"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579417000335"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2013.22"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/children1030390"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2019.12.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsv040"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000249732.96753.8f"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892\u2010020\u201001334\u20108"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2003.09.045"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.02.010"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.08.019"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(17)30118\u20104"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2016.08.002"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13217"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.10.002"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jan.12329"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/2327\u20106924.12215"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583\u2010199707000\u201000021"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892\u2010016\u20100751\u20105"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12846"},{"key":"e_1_2_8_32_1","first-page":"1","article-title":"CDC growth charts: United States","volume":"314","author":"Kuczmarski R. J.","year":"2000","journal-title":"Advance Data"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889\u2010019\u20107337\u20105"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/children5070098"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1610187"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0018\u2010506x(02)00024\u20107"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02088471"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16\u20101066"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18010236"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2017.08.004"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2011.10.005"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0033716"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8101638"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6300(1999)11:2<209::AID-AJHB9>3.0.CO;2-G"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.03.021"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2019.05.022"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2017.04.003"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acap.2017.01.008"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000536"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acap.2014.09.010"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/cdev.12118"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10865-008-9185-0"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003\u2010031503"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.06.014"}],"container-title":["Developmental Psychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dev.22127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dev.22127","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dev.22127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T20:10:19Z","timestamp":1692994219000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dev.22127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,15]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/dev.22127"],"URL":"https:\/\/doi.org\/10.1002\/dev.22127","archive":["Portico"],"relation":{},"ISSN":["0012-1630","1098-2302"],"issn-type":[{"value":"0012-1630","type":"print"},{"value":"1098-2302","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,15]]},"assertion":[{"value":"2020-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22127"}}