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In models of early\u2010life exposure, APAP has also been shown to alter anxiety\u2010related and other behaviors. Since the neuropeptide ghrelin has been recently shown to reduce oxidative stress markers and act as a neuroprotectant, we hypothesized that exposure to ghrelin prior to exposure to APAP would mitigate the behavioral effects of APAP exposure. On postnatal day 7, pups were administered doses of either APAP (51.97\u00a0mg\/kg), ghrelin (1\u00a0mg\/kg\/ml), ghrelin + APAP, or vehicle only. As adults, anxiety\u2010related behavior was assessed in the open field and elevated plus maze. Behavior differed based upon treatment condition. In rats unexposed to ghrelin, APAP treatment resulted in increased exploration (i.e., reduced anxiety) in the open field relative to controls. Rats co\u2010administered APAP and ghrelin did not differ from vehicle\u2010only controls. No significant effects of APAP or interactions between APAP and ghrelin exposures were observed in the elevated plus maze. These results are the first to demonstrate that ghrelin can mitigate the effects of perinatal APAP exposure in rats.<\/jats:p>","DOI":"10.1002\/dev.22252","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T06:25:14Z","timestamp":1647325514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Elevated ghrelin alters the behavioral effects of perinatal acetaminophen exposure in rats"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0692-9956","authenticated-orcid":false,"given":"Joshua A.","family":"Herrington","sequence":"first","affiliation":[{"name":"Department of Psychology Reed College  3203 SE Woodstock Blvd, Portland OR 97202, USA Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Guss Darwich","sequence":"additional","affiliation":[{"name":"Department of Psychology Reed College  3203 SE 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