{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:08:18Z","timestamp":1788887298072,"version":"build-2803163510"},"reference-count":96,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R15MH114035 to ACK"],"award-info":[{"award-number":["R15MH114035 to ACK"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The mechanisms that link maternal immune activation (MIA) with the onset of neurodevelopmental disorders remain largely unclear. Accelerated puberty is also associated with a heightened risk for psychopathology in later life, but there is a dearth of evidence on the impacts of maternal infection on pubertal timing. We examined the effects of MIA on reproductive development, mechanical allodynia, and sensorimotor gating in juvenile, adolescent, and adult male and female mice. Moreover, we investigated hypothalamic neural markers associated with the reproductive and stress axes. Finally, we tested the mitigating effects of environmental enrichment (EE), which has clinical relevancy in human rehabilitation settings. Our results show that administration of polyinosinic\u2013polycytidylic acid (poly(I:C)) on gestational day 12.5 led to early preputial separation, vaginal openings, and age of first estrus in offspring. MIA exposure altered pain sensitivity across development and modestly altered prepulse inhibition. The downregulation of\n                    <jats:italic>Nr3c1<\/jats:italic>\n                    and\n                    <jats:italic>Oprk<\/jats:italic>\n                    mRNA in the hypothalamus of juvenile mice suggests that MIA's effects may be mediated through disruption of hypothalamic\u2013pituitary\u2013adrenal axis activity. In contrast, life\u2010long housing with EE rescued many of these MIA\u2010induced consequences. Overall, our findings suggest that accelerated puberty may be associated with the deleterious effects of infection during pregnancy and the onset of psychopathology.\n                  <\/jats:p>","DOI":"10.1002\/dev.22278","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T06:50:05Z","timestamp":1650869405000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Maternal immune activation accelerates puberty initiation and alters mechanical allodynia in male and female C57BL6\/J mice"],"prefix":"10.1002","volume":"64","author":[{"given":"Xin","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Arts &amp; Sciences, Health Psychology Program Massachusetts College of Pharmacy and Health Sciences  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Erickson","sequence":"additional","affiliation":[{"name":"School of Arts &amp; Sciences, Health Psychology Program Massachusetts College of Pharmacy and Health Sciences  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruqayah","family":"Mohammed","sequence":"additional","affiliation":[{"name":"School of Arts &amp; Sciences, Health Psychology Program Massachusetts College of Pharmacy and Health Sciences  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7069-486X","authenticated-orcid":false,"given":"Amanda C.","family":"Kentner","sequence":"additional","affiliation":[{"name":"School of Arts &amp; Sciences, Health Psychology Program Massachusetts College of Pharmacy and Health Sciences  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302160"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-14-0315"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963721419837670"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/dev0000017"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1707152114"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579405050145"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1176\/ajp.156.4.596","article-title":"Symptom correlates of prepulse inhibition deficits in male schizophrenic patients","volume":"156","author":"Braff D. L.","year":"1999","journal-title":"American Journal of Psychiatry"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23842"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2016-0535"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2018.06.014"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0270233"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030450"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/bul0000270"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.06.020"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2406"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2013.05.006"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adolescence.2015.07.021"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12993-019-0154-2"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2005.06.025"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1011"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag3194"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000519141"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2021.100924"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1228261"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-17-05281.1996"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000054481"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2016.04.016"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.0943"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/2167702618810518"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3328-05.2005"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.08.004"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0552"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.11.011"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2019.01.010"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0185-7"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21775"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.03.013"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2018.07.029"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0539-20.2021"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.187"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(97)00008-0"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.08.006"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0022"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.08.004"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006354"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.04.048"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00027"},{"key":"e_1_2_9_50_1","article-title":"Double stranded RNA drives innate immune responses, sickness behavior and cognitive impairment dependent on dsRNA length, IFNAR1 expression and age","author":"McGarry N.","year":"2021","journal-title":"bioRxiv"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.07.144"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.04.031"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbn131"},{"key":"e_1_2_9_54_1","volume-title":"Applying regression and correlation: A guide for students and researchers","author":"Miles J.","year":"2001"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhaa057"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.04.019"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coemr.2020.06.009"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4288-11.2012"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00040"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.08.192"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43766"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.07.031"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0019"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.1999.00376.x"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.07.007"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.04.019"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200308000-00027"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.44"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.10.016"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod17.4.578"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21922"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbaa059"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-9-20"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-019-1122-0"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300767"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-01-00297.2003"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.08.013"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2019.01.003"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.09.008"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130051111"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.306"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/35044558"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2014.10.007"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(01)00543-1"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.02.021"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.05.008"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009077"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.10.007"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12313"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07236.x"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.01.052"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.02.009"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.03.018"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2020.100043"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12755"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300248"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2004.08.008"}],"container-title":["Developmental Psychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dev.22278","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dev.22278","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dev.22278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T19:17:59Z","timestamp":1692818279000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dev.22278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,25]]},"references-count":96,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/dev.22278"],"URL":"https:\/\/doi.org\/10.1002\/dev.22278","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.01.13.476235","asserted-by":"object"}]},"ISSN":["0012-1630","1098-2302"],"issn-type":[{"value":"0012-1630","type":"print"},{"value":"1098-2302","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,25]]},"assertion":[{"value":"2021-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22278"}}