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To illustrate the damages in the sensorimotor system, an adapted and validated model of neonatal anoxia is used. This study evaluated the sex differences in Wistar rats, neurological reflex, and motor development at the suckling period. Short\u2010 and long\u2010term impairments associated with sex differences were observed. In general, anoxic males were more affected in comparison to their control group and to anoxic females. Long\u2010lasting effects of the injury in adolescent rats predominately affected males. Similar to previous studies, we also found a decrease in the number of the substantia nigra cells in both sexes, compared to their control. So far, the results indicate that HIE caused neurobehavioral alterations and asymmetrical motor behavior with brain damage, possibly related to cognitive impairments previously observed at adolescence. These alterations may represent a useful endpoint for studying the efficacy of potential strategies that may improve the developmental consequences of a perinatal asphyxia insult in humans.<\/jats:p>","DOI":"10.1002\/dev.22291","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T07:08:33Z","timestamp":1657004913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sensorimotor development of male and female rats subjected to neonatal anoxia"],"prefix":"10.1002","volume":"64","author":[{"given":"Amrita Jha","family":"Kumar","sequence":"first","affiliation":[{"name":"Neuroscience Laboratory Department of Anatomy Institute of Biomedical Sciences Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6740-4283","authenticated-orcid":false,"given":"Ammir Yacoub","family":"Helou","sequence":"additional","affiliation":[{"name":"Neuroscience Laboratory Department of Anatomy Institute of Biomedical Sciences Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6995-6906","authenticated-orcid":false,"given":"Bruna Arruda","family":"Petrucelli","sequence":"additional","affiliation":[{"name":"Neuroscience Laboratory Department of Anatomy Institute of Biomedical Sciences Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8567-7031","authenticated-orcid":false,"given":"Gilberto Fernando","family":"Xavier","sequence":"additional","affiliation":[{"name":"Department of Physiology Institute of Biosciences Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3441-1820","authenticated-orcid":false,"given":"Daniel Oliveira","family":"Martins","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroanatomy Functional of Pain Departamento de Anatomia Instituto de Ciencias Biomedicas Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0172-4110","authenticated-orcid":false,"given":"Marucia","family":"Chacur","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroanatomy Functional of Pain Departamento de Anatomia Instituto de Ciencias Biomedicas Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria In\u00eas","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Neuroscience Laboratory Department of Anatomy Institute of Biomedical Sciences Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.187"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003\u20103472(75)90114\u20101"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.420040202"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647\u2010199607000\u201000022"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20108993(00)01997\u20101"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2016.08.001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2000.034"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2004.01.001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1179\/016164105X25216"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2019.11.001"},{"key":"e_1_2_9_12_1","unstructured":"DBCA \u2013 National Council for the Control of Animal Experimentation CONCEA. 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