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Demographic and health information included age, sex, race, household income, caregiver age and marital status, youth tobacco exposure, body mass index, pubertal status, health problems, medication use, and season of data collection. Genomic DNA was extracted from saliva, and T\/S ratios were computed following qPCR. Age, race, season of data collection, and household income were associated with the telomere to single copy (T\/S) ratio. We found that T\/S ratios were larger at younger ages, among Black youth, for saliva collected during autumn and winter, and among households with higher income. Analyses stratified by race revealed that the association between age and T\/S ratio was present for Black youth, that season of collection was present across races, but that family demographic associations with T\/S ratio varied by race. 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