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The BDNF Val66Met polymorphism is associated with reduced activity\u2010dependent BDNF release and increased risk for anxiety and depression. Male and female Val66Met rats were given access to running wheels from 3\u00a0weeks of age and compared to sedentary controls. Anxiety\u2010 and depression\u2010like behaviors were measured in adulthood using the elevated plus maze (EPM), open field (OF), and forced swim test (FST). Expression of BDNF and a number of stress\u2010related genes, the glucocorticoid receptor (<jats:italic>Nr3c1<\/jats:italic>), serum\/glucocorticoid\u2010regulated kinase 1 (<jats:italic>Sgk1<\/jats:italic>), and FK506 binding protein 51 (<jats:italic>Fkbp5<\/jats:italic>) in the hippocampus were also measured. Rats given access to running wheels developed high levels of voluntary exercise, decreased open\u2010arm time on the EPM and center\u2010field time in the OF, reduced overall exploratory activity in the open field, and increased immobility time in the FST with no differences between genotypes. Chronic exercise induced a significant increase in <jats:italic>Bdnf<\/jats:italic> mRNA and BDNF protein levels in the hippocampus with some of these effects being genotype specific. Exercise decreased the expression of <jats:italic>Nr3c1<\/jats:italic> and <jats:italic>Sgk1<\/jats:italic>, but increased the expression of <jats:italic>Fkbp5<\/jats:italic>. These results suggest that chronic running\u2010wheel exercise from adolescence increased anxiety and depression\u2010like phenotypes in adulthood, independent of BDNF Val66Met genotype. Further studies are required to confirm that increased indices of anxiety\u2010like behavior are independent from reduced overall locomotor activity.<\/jats:p>","DOI":"10.1002\/dev.22347","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T14:20:03Z","timestamp":1670509203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Chronic running\u2010wheel exercise from adolescence leads to increased anxiety and depression\u2010like phenotypes in adulthood in rats: Effects on stress markers and interaction with BDNF Val66Met genotype"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-1623","authenticated-orcid":false,"given":"Emily J.","family":"Jaehne","sequence":"first","affiliation":[{"name":"Department of Psychology, Counselling and Therapy School of Psychology and Public Health La Trobe University  Melbourne 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