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In a functional magnetic resonance imaging study, we investigated whether oxytocin regulates neural responses to reward or distress cues form children. In a placebo\u2010controlled, within\u2010subject design, we measured neural responses to positive, negative, and neutral cues from children in 22 healthy female subjects who received oxytocin (24 IU) versus placebo. Further, based on current literature, we hypothesized that oxytocin effects are modulated by experiences of childhood trauma. The task elicited valence\u2010specific effects\u2014positive images activated the ventromedial prefrontal cortex, left anterior cingulate cortex, and right putamen, and images of children in distress activated the bilateral amygdala, hippocampus, and right medial superior frontal cortex. The effects of oxytocin depended on subjective reports of childhood emotional neglect. Self\u2010reported neglect interacted with oxytocin administration in the amygdala, hippocampus, and prefrontal areas. In individuals with higher scores of emotional neglect, oxytocin increased neural reactivity of limbic structures to positive and neutral images. Our findings need replication in larger samples and can therefore be considered preliminary but are in line with the recent literature on the modulating effect of childhood adversity on the sensitivity to oxytocin administration.<\/jats:p>","DOI":"10.1002\/dev.22349","type":"journal-article","created":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T02:13:40Z","timestamp":1669428820000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preliminary data on oxytocin modulation of neural reactivity in women to emotional stimuli of children depending on childhood emotional neglect"],"prefix":"10.1002","volume":"65","author":[{"given":"Isabell M.","family":"Meier","sequence":"first","affiliation":[{"name":"Department of Experimental Psychology Utrecht University  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estrella R.","family":"Montoya","sequence":"additional","affiliation":[{"name":"Department of Experimental Psychology Utrecht University  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Spencer","sequence":"additional","affiliation":[{"name":"Research Institute of Child Development and Education University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0073-762X","authenticated-orcid":false,"given":"Sofia C.","family":"Orellana","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Cambridge, Cambridge Biomedical Campus  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u00ebt","family":"van Buuren","sequence":"additional","affiliation":[{"name":"Department of Clinical, Neuro and Developmental Psychology, Institute for Brain and Behavior Amsterdam Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"van Honk","sequence":"additional","affiliation":[{"name":"Department of Experimental Psychology Utrecht University  Utrecht The Netherlands"},{"name":"Department of Psychiatry and Mental Health, Groote Schuur Hospital, MRC Unit on Anxiety &amp; Stress Disorders University of Cape Town  Cape Town South Africa"},{"name":"Institute of Infectious Diseases and Molecular Medicine University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8944-0181","authenticated-orcid":false,"given":"Peter A.","family":"Bos","sequence":"additional","affiliation":[{"name":"Institute of Education and Child Studies Leiden University  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17470919.2014.948637"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956797610383439"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.05.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145\u20102134(02)00541\u20100"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00048"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl244"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579416000973"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPSYCHO.2021.108176"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.03.049"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22537"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2011.01.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsy080"},{"key":"e_1_2_8_14_1","unstructured":"Brett M. 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