{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:16:55Z","timestamp":1775146615114,"version":"3.50.1"},"reference-count":75,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prenatal stress (PS) results from a maternal experience of stressful events during pregnancy, which has been associated with an increased risk of behavioral disorders including substance abuse and anxiety in the offspring. PS is known to result in heightened dopamine release in the ventral tegmental area (VTA), in part through the effects of corticotropin\u2010releasing hormone, which directly excites dopaminergic cells. It has recently been suggested that agmatine plays a role in modulating anxiety\u2010like behaviors. In this study, we investigated whether agmatine could reduce negative cognitive outcomes in male mice prenatally exposed to psychological\/physical stress, and whether this could be associated with molecular changes in VTA. Agmatine (37.5\u00a0mg\/kg) was administrated 30\u00a0min prior to PS induction in pregnant Swiss mice. Male offspring were evaluated in a series of behavioral and molecular assays. Findings demonstrated that agmatine reduced the impairment in locomotor activity induced by both psychological and physical PS. Agmatine also decreased heightened conditioned place preference to morphine seen in PS offspring. Moreover, agmatine ameliorated the anxiety\u2010like behavior and drug\u2010seeking behavior induced by PS in the male offspring. Molecular effects were seen in VTA as the enhanced brain\u2010derived neurotrophic factor (BDNF) induced by PS in the VTA was reduced by agmatine. Behavioral tests indicate that agmatine exerts a protective effect on PS\u2010induced impairments in male offspring, which could be due in part to agmatine\u2010associated molecular alterations in the VTA. Taken together, our data suggest that prenatal treatment with agmatine exerts protective effect against negative consequences of PS on the development of affective circuits in the offspring.<\/jats:p>","DOI":"10.1002\/dev.22410","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T03:57:39Z","timestamp":1689307059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Preventive putative effect of agmatine on cognitive and molecular outcomes in ventral tegmental area of male offspring following physical and psychological prenatal stress"],"prefix":"10.1002","volume":"65","author":[{"given":"Amin","family":"Hassanshahi","sequence":"first","affiliation":[{"name":"Neuroscience Research Center, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahyar","family":"Janahmadi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moazamehosadat","family":"Razavinasab","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Neuropharmacology Institute Kerman University of Medical Sciences Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoda","family":"Ranjbar","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Neuropharmacology Institute Kerman University of Medical Sciences Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narges","family":"Hosseinmardi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gila","family":"Behzadi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristi A.","family":"Kohlmeier","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehran","family":"Ilaghi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Neuropharmacology Institute Kerman University of Medical Sciences Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-5849","authenticated-orcid":false,"given":"Mohammad","family":"Shabani","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Neuropharmacology Institute Kerman University of Medical Sciences Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.11.015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2155-07.2007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1304.014"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1304.016"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2005.05.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504626"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7608.1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-15-04707.1996"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2004.tb00128.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1120972"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/emph\/eov015"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)78174-5"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-017-0525-z"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2022.862390"},{"issue":"3","key":"e_1_2_9_16_1","first-page":"1033","article-title":"Acute and chronic opiate\u2010regulation of adenylate cyclase in brain: Specific effects in locus coeruleus","volume":"246","author":"Duman R. 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