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Adolescent males showed ethanol\u2010induced IL\u20106 conditioning more readily than adults. The present studies examined whether female adolescents display IL\u20106 conditioning and whether adolescents of either sex show CORT conditioning. Male and female (<jats:italic>N<\/jats:italic>\u00a0=\u00a0212, <jats:italic>n<\/jats:italic>\u00a0=\u00a06\u201310) adolescent (postnatal day 33\u201340) rats were given ethanol (2\u00a0g\/kg intraperitoneal injection; the unconditioned stimulus), either paired with a lavender\u2010scented novel context (the conditioned stimulus) or explicitly unpaired from context. Rats were tested in the context without ethanol and brains\/blood were collected. Adolescent females did not show signs of neuroimmune (Experiment 1) or CORT conditioning (Experiments 2\u20134). Paired males showed enhanced CORT to the scented context relative to unpaired counterparts when the interoceptive cue of a saline injection was used on test day (Experiment 2). Experiment 5 used a delayed conditioning procedure and showed that male paired adolescents showed significantly higher CORT in response to context, showing that classically conditioned CORT response was precipitated by environmental cues alone. These findings indicate that adolescent males may be predisposed to form conditioned associations between alcohol and environmental cues, contributing to adolescent vulnerability to long\u2010lasting ethanol effects.<\/jats:p>","DOI":"10.1002\/dev.22442","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T09:59:15Z","timestamp":1701856755000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cues associated with a single ethanol exposure elicit conditioned corticosterone responses in adolescent male but not female Sprague\u2013Dawley rats"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7403-9202","authenticated-orcid":false,"given":"Anny","family":"Gano","sequence":"first","affiliation":[{"name":"Developmental Exposure Alcohol Research Center (DEARC), Behavioral Neuroscience Program Department of Psychology Binghamton University  Binghamton New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thaddeus M.","family":"Barney","sequence":"additional","affiliation":[{"name":"Developmental Exposure Alcohol Research Center (DEARC), Behavioral Neuroscience Program Department of Psychology Binghamton University  Binghamton New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew S.","family":"Vore","sequence":"additional","affiliation":[{"name":"Developmental Exposure Alcohol Research Center (DEARC), Behavioral Neuroscience Program Department of Psychology Binghamton University  Binghamton New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie E.","family":"Mondello","sequence":"additional","affiliation":[{"name":"Developmental Exposure Alcohol Research Center (DEARC), Behavioral Neuroscience Program Department of Psychology Binghamton University  Binghamton New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena I.","family":"Varlinskaya","sequence":"additional","affiliation":[{"name":"Developmental Exposure Alcohol Research Center (DEARC), Behavioral Neuroscience Program Department of Psychology Binghamton University  Binghamton New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1876-2321","authenticated-orcid":false,"given":"Ricardo M.","family":"Pautassi","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n M\u00e9dica M. y M. 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