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Indeed, BDNF delivery has been efficacious in partially ameliorating many of the neurobiological and behavioral consequences of spinal cord injury (SCI), making elucidating the role of BDNF in the normative developing and injured spinal cord a critical research focus. Recent work in our laboratory provided evidence for aberrant global and locus\u2010specific epigenetic changes in methylation of the <jats:italic>Bdnf<\/jats:italic> gene as a consequence of SCI. In the present study, animals underwent thoracic lesions on P1, with cervical and lumbar tissue being later collected on P7, P14, and P21. Levels of <jats:italic>Bdnf<\/jats:italic> expression and methylation (exon IX and exon IV), in addition to global methylation levels were quantified at each timepoint. Results indicated locus\u2010specific reductions of <jats:italic>Bdnf<\/jats:italic> expression that was accompanied by a parallel increase in methylation caudal to the injury site, with animals displaying increased <jats:italic>Bdnf<\/jats:italic> expression at the P14 timepoint. Together, these findings suggest that epigenetic activity of the <jats:italic>Bdnf<\/jats:italic> gene may act as biomarker in the etiology and intervention effort efficacy following SCI.<\/jats:p>","DOI":"10.1002\/dev.22466","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T19:39:40Z","timestamp":1707334780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Epigenetic processes associated with neonatal spinal transection"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8536-170X","authenticated-orcid":false,"given":"Nicholas J.","family":"Collins","sequence":"first","affiliation":[{"name":"Department of Psychological and Brain Sciences University of Delaware  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor S.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of 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