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In rodents, prenatal and postnatal cocaine exposure enhanced locomotor activity and cocaine\u2010 or nicotine\u2010induced locomotor sensitization. Various authors consider that the adverse emotional states (anxiety and depression) that occur during cocaine withdrawal are the main factors that precipitate, relapse, and increase chronic cocaine abuse, which could increase the risk of relapse of cocaine abuse. Therefore, the objective of this study was to characterize anxiety\u2010 and depression\u2010like behaviors at different times (30, 60, 90, and 120 days) of cocaine withdrawal in rats born to females exposed prenatally and postnatally to cocaine. A group of pregnant female Wistar rats were administered daily from day GD0 to GD21 with cocaine (cocaine preexposure group), and another group of pregnant female rats was administered daily with saline (saline preexposure group). Of the litters resulting from the cocaine\u2010pre\u2010exposed and saline\u2010pre\u2010exposed pregnant female groups, only the male rats were used for the recording of the anxiety\u2010 and depression\u2010like behaviors at different times (30, 60, 90, and 120 days) of cocaine withdrawal The study found that prenatal and postnatal cocaine exposure dose\u2010dependent enhanced anxiety\u2010 and depression\u2010like behaviors. This suggests that prenatal and postnatal cocaine exposure can result in enhanced vulnerability to cocaine abuse in young and adult humans.<\/jats:p>","DOI":"10.1002\/dev.22493","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T05:19:47Z","timestamp":1713676787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prenatal and postnatal cocaine exposure enhances the anxiety\u2010 and depression\u2010like behaviors in rats during cocaine withdrawal"],"prefix":"10.1002","volume":"66","author":[{"given":"Susana Barbosa","family":"M\u00e9ndez","sequence":"first","affiliation":[{"name":"Subdirecci\u00f3n de Investigaciones Cl\u00ednicas. Laboratorio de Neurofarmacolog\u00eda Conductual, Microcirug\u00eda y Terap\u00e9utica Experimental. 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