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The hippocampus plays a key role in inhibition among adults and undergoes significant and rapid changes during early brain development. Therefore, the structure represents an important candidate region for early identification of pathology that is relevant to inhibitory dysfunction. To determine whether hippocampal function corresponds to inhibition in the early postnatal period, the present study evaluated relationships between hippocampal activity and sensory gating in infants 4\u201320 weeks of age (<jats:italic>N<\/jats:italic>\u00a0=\u00a018). Resting\u2010state functional magnetic resonance imaging was used to measure hippocampal activity, including the amplitude of low\u2010frequency fluctuations (ALFFs) and fractional ALFF. Electroencephalography during a paired\u2010stimulus paradigm was used to measure sensory gating (P50). Higher activity of the right hippocampus was associated with better sensory gating (P50 ratio), driven by a reduction in response to the second stimulus. These findings suggest that meaningful effects of hippocampal function can be detected early in infancy. Specifically, higher intrinsic hippocampal activity in the early postnatal period may support effective inhibitory processing. Future work will benefit from longitudinal analysis to clarify the trajectory of hippocampal function, alterations of which may contribute to the risk of neurodevelopmental disorders and represent an intervention target.<\/jats:p>","DOI":"10.1002\/dev.22529","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T06:20:21Z","timestamp":1721110821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intrinsic Infant Hippocampal Function Supports Inhibitory Processing"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4576-5037","authenticated-orcid":false,"given":"Anika","family":"Guha","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon K.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina T.","family":"Legget","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Colorado Anschutz Medical Campus  Aurora Colorado USA"},{"name":"Research Service Rocky Mountain Regional VA Medical Center  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen","family":"McHugo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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