{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T19:37:50Z","timestamp":1787427470583,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Obsessive\u2010compulsive disorder is a neuropsychiatric condition with notable genetic involvement. Against this background, laboratory\u2010housed deer mice of both sexes varyingly present with excessive and persistent large nesting behavior (LNB), which has been validated for its resemblance of clinical compulsivity. Although LNB differs from normal nesting behavior (NNB) on both a biological and cognitive level, it is unknown to what extent the expression of LNB and NNB is related to familial background. Here, we randomly selected 14 NNB\u2010 and 14 LNB\u2010expressing mice (equally distributed between sexes) to constitute 7 breeding pairs of each phenotype. Pairs were allowed to breed two successive generations of offspring, which were raised until adulthood (12 weeks) and assessed for nesting expression. Remarkably, our findings show that offspring from LNB\u2010expressing pairs build significantly larger nests compared to offspring from NNB\u2010expressing pairs and the nesting expression of the offspring of each breeding pair, irrespective of parental phenotype or litter, is family specific. Collectively, the results of this investigation indicate that LNB can be explored for its potential to shed light on heritable neurocognitive mechanisms that may underlie the expression of specific persistent behavioral phenotypes.<\/jats:p>","DOI":"10.1002\/dev.22533","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T19:00:05Z","timestamp":1722970805000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adult Offspring of Deer Mouse Breeding Pairs Selected for Normal and Compulsive\u2010Like Large Nesting Expression Invariably Show the Same Behavior Without Prior In\u2010Breeding"],"prefix":"10.1002","volume":"66","author":[{"given":"Heike","family":"Stoppel","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Health Sciences Centre of Excellence for Pharmaceutical Sciences North\u2010West University  Potchefstroom South 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