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These pathways play an important role in regulating cognitive behaviors later in life. Despite this, there has been very little research regarding the potential long\u2010term effects of 17\u2010OHPC on the behavioral and neural development of exposed children. In rodents, developmental exposure to 17\u2010OHPC disrupts serotonergic and dopaminergic innervation of the medial prefrontal cortex and impairs decision\u2010making in complex cognitive tasks in adulthood. The present study tested the hypothesis that developmental exposure to 17\u2010OHPC similarly disrupts the development of serotonergic and dopaminergic pathways within limbic targets and subsequent mood\u2010related behaviors. Developmental 17\u2010OHPC exposure significantly increased the density of serotonin transporter\u2013IR fibers in CA1, CA2\/3, and the suprapyramidal blade of dentate gyrus in hippocampus and significantly reduced the density of TH\u2010IR fibers within the nucleus accumbens shell in males but had no effect in females during adolescence. Irregular microglia activational phenotype and number were also observed in the hippocampus of 17\u2010OHPC\u2010exposed males. Developmental 17\u2010OHPC reduced the latency to immobility in males in the forced swim test but did not affect sucrose consumption in a sucrose preference test. These findings suggest that 17\u2010OHPC exerts sex\u2010specific effects on the development of mesocorticolimbic pathways and mood\u2010related behavior in adolescence and highlight the need to investigate effects in adolescent children.<\/jats:p>","DOI":"10.1002\/dev.22536","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T02:00:36Z","timestamp":1724292036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Implications of Developmental 17\u2010OHPC Exposure on the Mesocorticolimbic Serotonergic and Dopaminergic Pathways and Adolescent Mood\u2013Related Behavior in Rats"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3900-0126","authenticated-orcid":false,"given":"Paige L.","family":"Graney","sequence":"first","affiliation":[{"name":"Department of Psychology &amp; Center for Neuroscience Research University at Albany  Albany New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn L.","family":"Sarno","sequence":"additional","affiliation":[{"name":"Department of Psychology &amp; Center for Neuroscience Research University at Albany  Albany New York USA"},{"name":"Albany College of Pharmacy and Health Sciences  Albany New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessie E.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Psychology &amp; Center for Neuroscience Research University at Albany  Albany New York USA"},{"name":"Albany Law School  Albany New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine K.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Psychology &amp; Center for Neuroscience Research University at Albany  Albany New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/2022.03.09.483609"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.03.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.05.024"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2018.10.028"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.17\u201002\u201000851.1997"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0306-4522(98)00583-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903160305"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.03.010"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.10.003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.08.015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11713"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20229"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/385070a0"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460\u20109568.2002.02027.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306\u20104522(92)90007\u2010O"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22847"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","unstructured":"Friemel.2010. \u201cReward Sensitivity for a Palatable Food Reward Peaks During Pubertal Developmental in Rats.\u201dFrontiers in Behavioral Neuroscience.https:\/\/doi.org\/10.3389\/fnbeh.2010.00039.","DOI":"10.3389\/fnbeh.2010.00039"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22772"},{"key":"e_1_2_9_20_1","unstructured":"Graney P. 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