{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T07:47:06Z","timestamp":1757576826262},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":4578,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Behavioral and neuromorphological data have suggested at least a partial interaction between the effects of norepinephrine\u2010depleting neonatal 6\u2010OHDA lesions and the effects of rearing in enriched environments. The present study examined the impact of both of these early manipulations upon regional brain uptake of <jats:sup>14<\/jats:sup>C\u20102\u2010deoxyglucose (<jats:sup>14<\/jats:sup>C\u20102DG) in adulthood. Newborn rats received 6\u2010OHDA (50 mg\/kg s.c.) or vehicle and, after weaning at 25 days, were reared in isolated versus enriched conditions. Regional brain <jats:sup>14<\/jats:sup>C\u20102DG uptake was then examined at 70\u201380 days of age\u2014either in the home cage or while animals were being exposed to novel, presumably arousing, stimulation. Ninety\u2010seven brain regions were examined in eight separate groups. Results indicated that (1) Under baseline conditions, neither neonatal 6\u2010OHDA nor differential rearing conditions produced widespread alterations in regional brain <jats:sup>14<\/jats:sup>C\u20102DG uptake profiles. An overall enrichment effect was on only five brain areas, with rats reared in enriched environments showing lower levels of <jats:sup>14<\/jats:sup>C\u20102DG uptake (\u221220% to \u221230%) than isolated rats. Neonatai 6\u2010OHDA produced no main effect on <jats:sup>14<\/jats:sup>C\u20102DG uptake in any brain region. (2) In contrast, when <jats:sup>14<\/jats:sup>C\u20102DG uptake was assessed during exposure to a novel environment, five brain areas showed differential <jats:sup>14<\/jats:sup>C\u20102DG uptake in 6\u2010OHDA\u2010treated rats, and 20 brain areas showed differential uptake in rats reared in enriched conditions. (3) No significant interaction effect on brain regional <jats:sup>14<\/jats:sup>C\u20102DG uptake was observed between neonatal 6\u2010OHDA and environmental complexity factors. These results are consistent with the notion that enduring effects of rearing and early 6\u2010OHDA treatment may, independently, relate to a general reactivity factor. They also indicate that some effects of early neurochemical injury and subsequent experiential factors may not be apparent under normal resting conditions, but only become evident in the presence of appropriate \u201cactivating\u201d stimulation. \u00a9 1992 Wiley &amp; sons. Inc.<\/jats:p>","DOI":"10.1002\/dev.420250304","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T23:34:37Z","timestamp":1104622477000},"page":"183-198","source":"Crossref","is-referenced-by-count":13,"title":["Neonatal 6\u2010OHDA lesions and rearing in complex environments: Regional effects on adult brain <sup>14<\/sup>C\u20102\u2010deoxyglucose uptake revealed by exposure to novel stimulation"],"prefix":"10.1002","volume":"25","author":[{"given":"Jos\u00e9 N.","family":"Nobrega","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti J.","family":"Saari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John N.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trudy","family":"Reed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1985.sp015815"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03326513"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/320172a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.163.3869.825"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(83)90414-7"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(85)90282-1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(87)90147-8"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(83)90138-9"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901310305"},{"key":"e_1_2_1_11_1","first-page":"1232","article-title":"Local rates of cerebral glucose utilization in adult male rats following 30 days of an enriched environment","volume":"12","author":"Diamond M. 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