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Administration of the D1\u2010like agonist SKF 38393 (30.0 mg\/kg) or the D2\u2010like agonist quinpirole (3.0 mg\/kg) increased the incidence of sniffing and locomotion in intact and DA\u2010depleted animals tested at either age. However, the ability of selective DA antagonists to reduce these stimulated responses interacted with both the depletion and the age at the time of testing. When tested as pups, both the D1 antagonist SCH 23390 (0.2 or 0.4 mg\/kg) and the D2 antagonist clebopride (10.0 mg\/kg) suppresed the behaviors induced by either class of DA agonist. When tested as weanlings, intact animals exhibited the profile of pups (i.e., either class antagonist blocked each agonist). In DA\u2010depleted weanlings, however, only the D1 antagonist blocked the D1 agonist\u2010induced responses and only the D2 antagonist blocked the D2 agonist\u2010induced responses. These data demonstrate that the interactions between D1 and D2 receptors in the expression of stimulated motor behaviors are altered following DA depletions in neonates. Moreover, this change in receptor function occurs sometime between 7 and 13 days after the DA depletion.\u00a91994 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/dev.420270608","type":"journal-article","created":{"date-parts":[[2005,1,2]],"date-time":"2005-01-02T00:12:57Z","timestamp":1104624777000},"page":"409-424","source":"Crossref","is-referenced-by-count":8,"title":["Development of uncoupling between D1\u2010 and D2\u2010 mediated motor behavior in rats depleted of dopamine as neonates"],"prefix":"10.1002","volume":"27","author":[{"given":"Elizabeth Mccone","family":"Byrnes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.420250703"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(85)90345-0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(84)90267-X"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/347386a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(86)90588-1"},{"key":"e_1_2_1_7_1","first-page":"343","article-title":"Behavioral differences between neonatal and adult 6\u2010hydroxydopamine\u2010treated rats todopamine agonists: Relevance to meurological symptoms in clinical syndromes with reduced brain dopamine","volume":"231","author":"Breese G. 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