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Infants prenatally exposed to medications for opioid use disorder (MOUD), however, commonly show signs of neonatal opioid withdrawal syndrome (NOWS), which can include feeding\u2010related issues like hyperphagia. To investigate the effects of prenatal MOUD exposure on feeding behavior, female Sprague\u2010Dawley rats were implanted with osmotic minipumps filled with methadone, buprenorphine, or saline and subsequently mated. On postnatal day (PND) 1, buprenorphine\u2010 and methadone\u2010exposed offspring weighed less than saline\u2010exposed subjects. Throughout early postnatal development (PND2, 7, and 12), this reduction in weight persisted in buprenorphine, but not methadone, offspring. RNAscope in situ hybridization was then used to measure expression of genes in the nucleus accumbens (NAc) previously associated with hyperphagia in NOWS infants, including proopiomelanocortin (<jats:italic>Pomc<\/jats:italic>), neuropeptide Y2 receptors (<jats:italic>Npy2r<\/jats:italic>), and dopamine type 2 receptors (<jats:italic>Drd2<\/jats:italic>). Distinct developmental expression patterns were noted across the postnatal period, with few effects of MOUD; however, significantly lower <jats:italic>Pomc<\/jats:italic> expression was observed in methadone\u2010exposed but not buprenorphine\u2010exposed offspring. These findings demonstrate differential effects of methadone and buprenorphine on offspring development and gene expression, highlighting differences in offspring outcomes associated with these two MOUDs.<\/jats:p>","DOI":"10.1002\/dev.70015","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T04:14:01Z","timestamp":1733717641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Differential Effects of Prenatal Buprenorphine and Methadone on Postnatal Growth and Gene Expression in the Nucleus Accumbens"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3324-141X","authenticated-orcid":false,"given":"Kelsea R.","family":"Gildawie","sequence":"first","affiliation":[{"name":"Department of Comparative Pathobiology, Cummings School of Veterinary Medicine Tufts University  North Grafton Massachusetts USA"},{"name":"Department of Psychology Simmons University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9544-7491","authenticated-orcid":false,"given":"Kerri E.","family":"Budge","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathobiology, Cummings School of Veterinary Medicine Tufts University  North Grafton Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fair M.","family":"Vassoler","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathobiology, Cummings School of Veterinary Medicine Tufts University  North Grafton Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tufts University School of Medicine  Boston Massachusetts USA"},{"name":"Mother Infant Research Institute Tufts Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Byrnes","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathobiology, Cummings School of Veterinary Medicine Tufts University  North Grafton Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,8]]},"reference":[{"issue":"10","key":"e_1_2_9_2_1","first-page":"1722","article-title":"Rooming\u2010in Compared With Standard Care for Newborns of Mothers Using Methadone or Heroin","volume":"53","author":"Abrahams R. 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