{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:46:54Z","timestamp":1773013614103,"version":"3.50.1"},"reference-count":80,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH122447"],"award-info":[{"award-number":["MH122447"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES032294"],"award-info":[{"award-number":["ES032294"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH126468"],"award-info":[{"award-number":["MH126468"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA055338"],"award-info":[{"award-number":["DA055338"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99HD113873"],"award-info":[{"award-number":["K99HD113873"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fetal iron status has long\u2010lasting effects on neurodevelopmental outcomes and risk of psychopathology. Although prenatal exposure to maternal psychological stress has been linked to offspring peripheral iron status at birth, it is unknown whether maternal prenatal stress is related to fetal brain iron during gestation. We utilized 86 multi\u2010echo functional magnetic resonance imaging (fMRI) scans from 52 fetuses (23 females; gestational age [GA] 24\u201338 weeks) to estimate R2* relaxometry as a proxy for fetal brain iron levels. Our results showed that greater maternal anxiety symptoms were associated with higher estimated fetal iron levels in the left cerebellar vermis after controlling for fetal sex and GA. Our finding suggests that fetal brain iron levels may be sensitive to exposure to maternal stress in utero. In a subset of participants with available infant outcome data (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a031), no significant associations were found between fetal brain iron levels and later cognitive, language, and motor development during infancy. Overall, this study presents the first evidence of associations between maternal prenatal stress and fetal brain iron, which lays the groundwork for future investigations of biological embedding of prenatal maternal stress on the fetal brain and later neurodevelopment through prenatal iron accumulation as a potential mechanism.\n                  <\/jats:p>","DOI":"10.1002\/dev.70062","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T03:51:33Z","timestamp":1751860293000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal Prenatal Psychological Stress and Iron Levels in the Fetal Brain"],"prefix":"10.1002","volume":"67","author":[{"given":"Bosi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry New York University School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanxin","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry New York University School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngwoo Bryan","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry New York University School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Duffy","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry New York University School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Menu","sequence":"additional","affiliation":[{"name":"LaPsyD\u00c9, Universit\u00e9 Paris Cit\u00e9, CNRS  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Trentacosta","sequence":"additional","affiliation":[{"name":"Department of Psychology Wayne State University  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moriah E.","family":"Thomason","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry New York University School of Medicine  New York New York USA"},{"name":"Department of Population Health New York University School of Medicine  New York New York USA"},{"name":"Neuroscience Institute New York University School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.09.049"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.27"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm\u20102012\u20100125"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20758"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.1.47"},{"issue":"4","key":"e_1_2_8_7_1","first-page":"821","article-title":"MRI Evaluation of Basal Ganglia Ferritin Iron and Neurotoxicity in Alzheimer's and Huntingon's Disease","volume":"46","author":"Bartzokis G.","year":"2000","journal-title":"Cellular and Molecular Biology"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2015.03.017"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448514"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.5.1468S"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.23.020102.075739"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26471"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9121327"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-6383(01)00062-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.07.010"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2010.12.005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cdn\/nzaa018"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753\u20104887.2012.00550.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.108.096354"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0301\u20105629(00)00225\u20108"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006\u20103223(03)00698\u2010x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2307\/2136404"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13103530"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2011.570376"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.04.065"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065\u2010015\u20109292\u2010y"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.12"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22162"},{"key":"e_1_2_8_29_1","first-page":"143","article-title":"Examining Cut\u2010Off Values FOR The State\u2010Trait Anxiety Inventory\/Examinando Los Puntajes De Corte Para El Inventario De Ansiedad Estado\u2010Rasgo","author":"Ercan I.","year":"2015","journal-title":"Revista Argentina De Cl\u00ednica Psicol\u00f3gica"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.155812"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.08.035"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0361267"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.155846"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201000525\u2010w"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.155853"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2021.10.012"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2017.6807"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00034"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2018.05.004"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469\u20107610.00166"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.10.1136"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.70073"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2014.10"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmab035"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex079"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141089"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2011.02.003"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.2434\u201019.2020"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102431\u201011\u201062"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010023\u201002399\u2010z"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004\u20101169"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.09.010"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702\u2010010\u20100434\u20103"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12000"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.248"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2021.100368"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2022.11.023"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.4.924"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469\u20107610.00187"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20207"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2021.100999"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.10.3215"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2024.100824"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15173798"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.04.040"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/87565640903265145"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.2910"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010nutr\u2010061021\u2010030404"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu208"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000127021.38207.62"},{"key":"e_1_2_8_71_1","volume-title":"State\u2010Trait Anxiety Inventory: Bibliography","author":"Spielberger C.","year":"1989"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(14)61277\u20100"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u20108624.2004.00727.x"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.07.003"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201081681\u2010y"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2018.02.001"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117216"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(14)70117\u20106"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.145961"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.08.009"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2016.20"}],"container-title":["Developmental Psychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dev.70062","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dev.70062","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dev.70062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:31:42Z","timestamp":1773009102000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dev.70062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":80,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/dev.70062"],"URL":"https:\/\/doi.org\/10.1002\/dev.70062","archive":["Portico"],"relation":{},"ISSN":["0012-1630","1098-2302"],"issn-type":[{"value":"0012-1630","type":"print"},{"value":"1098-2302","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70062"}}