{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:34:14Z","timestamp":1786700054723,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008001","name":"Universit\u00e4t zu K\u00f6ln","doi-asserted-by":"publisher","award":["UoC2022"],"award-info":[{"award-number":["UoC2022"]}],"id":[{"id":"10.13039\/501100008001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Stress\u2010induced physiological changes offer insights into autonomic nervous system (ANS) function beyond resting cardiac activity, relevant to both physical and mental illnesses. Limited research exists on heart rate (HR) reactivity in children and adolescents, particularly in the context of internalizing psychopathology. In a study of\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a048 typically developing adolescents (mean age 16.31\u00a0years, SD\u00a0=\u00a00.51), HR and vagal\u2010mediated heart rate variability (vmHRV) were assessed by electrocardiography during an orthostatic challenge, which served as a standardized physiological stressor. Regression models examined the association between HR metrics (baseline, reactivity, recovery) and self\u2010reported internalizing psychopathology (depression and anxiety). Higher levels of internalizing psychopathology were negatively associated with vmHRV reactivity and recovery, and these associations were moderated by sex. Levels of anxiety and depression showed a stronger negative association with vmHRV reactivity in boys than girls, and anxiety levels showed a unique association with reduced vmHRV recovery in boys. These findings highlight sex\u2010specific patterns in ANS functioning related to internalizing symptoms and stress\u2010induced physiological responses in youth.\n                  <\/jats:p>","DOI":"10.1002\/dev.70135","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T07:13:08Z","timestamp":1770361988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Cardiac Orthostatic Stress Response as a Function of Internalizing Psychopathology and Sex in Typically Developing Youth\u2014An Observational Study"],"prefix":"10.1002","volume":"68","author":[{"given":"Luise","family":"Baumeister\u2010Lingens","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Markser","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander L.","family":"Gerlach","sequence":"additional","affiliation":[{"name":"Department of Psychology, Institute of Clinical Psychology and Psychotherapy University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kaess","sequence":"additional","affiliation":[{"name":"University Hospital of Child and Adolescent Psychiatry and Psychotherapy University of Bern  Bern Switzerland"},{"name":"Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romuald","family":"Brunner","sequence":"additional","affiliation":[{"name":"Clinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Koenig","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.07.027"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2015.08.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chc.2012.05.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20108986.1997.tb02140.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000019"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780203774441"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.chi.0000184929.41423.c0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"e_1_2_9_10_1","volume-title":"Brief Symptom Inventory (BSI)","author":"Derogatis L. 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