{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:48:04Z","timestamp":1791798484655,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD093627"],"award-info":[{"award-number":["R01HD093627"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pregnancy represents a critical juncture for intergenerational transmission of stress\u2010related health vulnerabilities when child\u2010bearers\u2019 history of maltreatment may precipitate stress responses that adversely impact maternal and fetal outcomes. We aimed to shed light on this path by testing hypotheses that (1) childhood maltreatment would predict oral inflammatory responses to acute stress in late pregnancy, and (2) these inflammatory responses would relate to subsequent obstetric complications. Hypotheses were tested in a community sample of women (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0158) from a larger longitudinal study. Participants reported a history of maltreatment and completed the Trier Social Stress Test during the third trimester of pregnancy. Five saliva samples collected before and after the task were assayed for pro\u2010inflammatory cytokines (IL1\u03b2, IL6, TNF\u03b1) and C\u2010reactive protein (CRP) to index oral inflammation. At 3\u00a0months postnatal, women reported pregnancy and birth complications, and birth outcomes. Multilevel models of inflammatory response trajectories supported hypothesized paths: Greater childhood maltreatment\u2014especially physical neglect and sexual abuse\u2014predicted higher and\/or extended inflammatory stress responses. In turn, higher inflammatory stress responses related to greater pregnancy and birth complications, and extended inflammatory responses related to a greater likelihood of preterm birth. Findings support oral inflammatory response to stress as a potential link to target in intergenerational health risk transmission.\n                  <\/jats:p>","DOI":"10.1002\/dev.70178","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:08:32Z","timestamp":1782889712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammatory Stress Response During Pregnancy as a Connecting Link in Intergenerational Risk Cascades"],"prefix":"10.1002","volume":"68","author":[{"given":"Heidemarie K.","family":"Laurent","sequence":"first","affiliation":[{"name":"Department of Human Development and Family Studies Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Department of Psychology University of Illinois Urbana\u2010Champaign  Champaign Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherryl H.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Department of Psychology Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen D.","family":"Rudolph","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Illinois Urbana\u2010Champaign  Champaign Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kento","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Human Development and Family Studies Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penina","family":"Backer","sequence":"additional","affiliation":[{"name":"Department of Human Development and Family Studies Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aastha","family":"Dhimal","sequence":"additional","affiliation":[{"name":"Department of Biology Pennsylvania State University Harrisburg Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Pikhit","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Pennsylvania State University University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Granger","sequence":"additional","affiliation":[{"name":"Institute for Interdisciplinary Salivary Bioscience Research University of California Irvine Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.so.18.080192.000311"},{"key":"e_1_2_9_3_1","volume-title":"Childhood Trauma Questionnaire: A Retrospective Self\u2010Report Manual","author":"Bernstein D. 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