{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:56:52Z","timestamp":1790776612869,"version":"4.1.0"},"reference-count":80,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP86458"],"award-info":[{"award-number":["MOP86458"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012120","name":"Ontario Mental Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012120","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010785","name":"Canada First Research Excellence Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Adolescents of mothers with a history of depression are at increased risk for developing depression themselves. These adolescents may have been especially vulnerable to depression under conditions of stress, such as the beginning of the COVID\u201019 pandemic. To understand the complex processes involved in the transmission of maternal depression risk to adolescent offspring in the context of stress, we examined potential mediating and moderating factors that link maternal depression history and offspring depressive symptoms, including resting\u2010state functional connectivity (rs\u2010FC) and mothers\u2019 depressive symptoms, in 85 adolescents during the pandemic. Adolescents\u2019 prepandemic rs\u2010FC between the posterior and anterior cingulate cortices (PCC\u2013ACC) moderated the association between maternal depression history and adolescents\u2019 symptoms during the pandemic, such that maternal depression history predicted adolescents\u2019 symptoms only in youths with heightened PCC\u2013ACC rs\u2010FC. Mothers\u2019 depressive symptoms during the pandemic mediated and moderated the link between maternal depression history and adolescents\u2019 symptoms. Mothers with a history of depression had greater depressive symptoms early during the pandemic, which were further associated with offspring depressive symptoms. Additionally, maternal depression history predicted depressive symptoms in adolescents whose mothers had lower depressive symptoms during the pandemic. Findings speak to the mediating and moderating processes in the transmission of maternal depression risk to adolescent offspring in the context of the pandemic.<\/jats:p>","DOI":"10.1002\/dev.70209","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:07:36Z","timestamp":1790773656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal Depression, Childhood Resting\u2010State Brain Connectivity, and Adolescent Depression During the COVID\u201019 Outbreak"],"prefix":"10.1002","volume":"68","author":[{"given":"Pan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Psychology, Brain &amp; Mind Institute Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R. 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