{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T21:33:18Z","timestamp":1784583198942,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,4,8]],"date-time":"2010-04-08T00:00:00Z","timestamp":1270684800000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Resveratrol (RSV) has been shown to ameliorate hyperglycaemia and hyperlipidaemia in streptozotocin\u2010induced diabetic rats. In the present study, we examined the beneficial effects of RSV on diabetes mellitus (DM)\u2010induced vasculopathy and explored its possible mechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male Sprague\u2013Dawley rats were injected with streptozotocin at 65 mg\/kg body weight The induction of DM was confirmed by a fasting plasma glucose level \u2265 300 mg\/dL and symptoms of polyphagia and polydipsia. The DM rats were treated with or without RSV at 0.75 mg\/kg body weight three times a day for 4\u20138 weeks. Animals were sacrificed and vessel wall histology was examined by microscopy. The vascular smooth muscle cell activation was assessed by the medial thickness, collagen deposition, and the expressions receptor for advanced glycation end product, NF\u2010\u03baB, proliferation cell nuclear antigen, and the levels of Erk1\/2 phosphorylation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In RSV\u2010treated DM rats, the vascular wall thickening, collagen deposition\/cross\u2010linking, and vascular permeability were all alleviated compared with that of the untreated DM rats. The vascular smooth muscle cell of the RSV\u2010treated rats was characterized with less proliferation, lower NF\u2010\u03baB, and Erk1\/2 activation, decreased proliferation cell nuclear antigen and receptor for advanced glycation end product expression. Moreover, the plasma fructosamine was significantly reduced in RSV\u2010treated DM rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>RSV alleviated DM\u2010induced vasculopathy through attenuation of advanced glycation end product\u2013receptor for advanced glycation end product\u2013NF\u2010\u03baB signalling pathway. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.1076","type":"journal-article","created":{"date-parts":[[2010,4,8]],"date-time":"2010-04-08T04:41:00Z","timestamp":1270701660000},"page":"212-222","source":"Crossref","is-referenced-by-count":50,"title":["Resveratrol ameliorates vasculopathy in STZ\u2010induced diabetic rats: role of AGE\u2013RAGE 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