{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:22:42Z","timestamp":1773915762931,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,9,2]],"date-time":"2010-09-02T00:00:00Z","timestamp":1283385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In the early identification of cardiovascular risk, it is essential to establish a biological marker for cardiac complications that is comparable to albuminuria for nephropathy. We tested the hypothesis that <jats:italic>N<\/jats:italic>\u2010terminal pro\u2010brain natriuretic peptide (NT\u2010proBNP) might be a marker for silent myocardial ischaemia in diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In forty consecutively recruited subjects without evident coronary artery disease, serum NT\u2010proBNP was measured together with multi\u2010slice computed tomography. With patients suspected of having significant coronary artery stenosis by multi\u2010slice computed tomography, coronary angiography was performed. Silent myocardial ischaemia was defined as the presence of significant coronary artery stenosis with more than 50% luminal narrowing by angiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen patients (32.5%) had silent myocardial ischaemia. NT\u2010proBNP levels were significantly higher in these patients (181.1 \u00b1 43.8 <jats:italic>versus<\/jats:italic> 55.2 \u00b1 9.7 pg\/mL, <jats:italic>p<\/jats:italic> &lt; 0.005) but HbA<jats:sub>1c<\/jats:sub>, lipid profiles, and creatinine were similar in the two groups. Moreover, log NT\u2010proBNP was identified as an independent predictor of silent myocardial ischaemia (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.502, <jats:italic>p<\/jats:italic> &lt; 0.05) after adjustment for HbA<jats:sub>1c<\/jats:sub>, creatinine, albuminuria, hypertension, hyperlipidaemia, or smoking. After stratifying patients by NT\u2010proBNP, the upper tertile compared to the lowest tertile was significantly associated with silent myocardial ischaemia (odds ratio: 26.7, <jats:italic>p<\/jats:italic> &lt; 0.05). Receiver operation characteristics analysis with a cut\u2010off value of 52 pg\/mL showed 92% sensitivity and 75% specificity for predicting silent myocardial ischaemia (positive predictive value 64.7%, negative predictive value 94.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The outstandingly high negative predictive value of NT\u2010proBNP enables us to focus on diabetic patients with occult coronary disease, independently of microalbuminuria. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.1113","type":"journal-article","created":{"date-parts":[[2010,9,3]],"date-time":"2010-09-03T17:34:48Z","timestamp":1283535288000},"page":"534-539","source":"Crossref","is-referenced-by-count":8,"title":["<i>N<\/i>\u2010terminal fragment of pro\u2010brain natriuretic peptide (NT\u2010proBNP) for predicting silent myocardial ischaemia in type 2 diabetes mellitus independent of microalbuminuria"],"prefix":"10.1002","volume":"26","author":[{"given":"Kumiko","family":"Hamano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rieko","family":"Komi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzo","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,9,2]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809243391301"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1396"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.8.1954"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01910.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1470649"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1062-4"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.2.169"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000130845.38133.8F"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.025"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0359-4"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2004.01396.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(01)00365-5"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.09215.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.11.013"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215540205000606"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.6.1.109"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn334"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(08)70097-1"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2009.02788.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.12.2905"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdmrr.1113","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.1113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T13:19:49Z","timestamp":1697030389000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.1113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,2]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1002\/dmrr.1113"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.1113","archive":["Portico"],"relation":{},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,2]]}}}