{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:48:58Z","timestamp":1791341338880,"version":"4.3.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,5,6]],"date-time":"2011-05-06T00:00:00Z","timestamp":1304640000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Individual effects of hyperglycaemia and obesity to impair vascular health are recognized. However, the relative contributions of dysglycaemia <jats:italic>versus<\/jats:italic> other obesity\u2010related traits to vascular dysfunction have not been systematically evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We undertook a cross\u2010sectional evaluation of factors contributing to vascular function in 271 consecutive subjects, categorized as non\u2010obese normal glucose tolerant (<jats:italic>n<\/jats:italic> = 115), non\u2010obese dysglycaemic (<jats:italic>n<\/jats:italic> = 32), obese normal glucose tolerant (<jats:italic>n<\/jats:italic> = 57), obese dysglycaemic (<jats:italic>n<\/jats:italic> = 38), or type 2 diabetic (<jats:italic>n<\/jats:italic> = 29). Vascular function was measured invasively as leg blood flow responses to methacholine chloride, an endothelium\u2010dependent vasodilator. Categorical and continuous analyses were carried out to assess the contributions of hyperglycaemia to vascular dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Even among normoglycaemic subjects, obese subjects had impaired vascular function compared to non\u2010obese subjects (<jats:italic>p<\/jats:italic> = 0.004). Vascular function was also impaired in non\u2010obese dysglycaemic subjects (<jats:italic>p<\/jats:italic> = 0.04 <jats:italic>versus<\/jats:italic> non\u2010obese normoglycaemic subjects), to a level comparable to normoglycaemic obese subjects. Within obese subject groups, gradations of dysglycaemia including the presence of diabetes were not associated with further worsening of these vascular responses beyond the effect of obesity alone (<jats:italic>p<\/jats:italic> = not significant comparing all obese groups, <jats:italic>p<\/jats:italic> &lt; 0.001 <jats:italic>versus<\/jats:italic> lean normoglycaemic subjects). After univariate and multivariable modelling analyses we found that effects of glycaemia were less powerful than effects of insulin resistance and obesity on vascular dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dysglycaemia contributes to impaired vascular function in non\u2010obese subjects, but obesity and insulin resistance are more important determinants of vascular function in obese and diabetic subjects. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.1183","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T06:49:05Z","timestamp":1296542945000},"page":"354-361","source":"Crossref","is-referenced-by-count":33,"title":["Contributions of dysglycaemia, obesity, and insulin resistance to impaired endothelium\u2010dependent vasodilation in humans"],"prefix":"10.1002","volume":"27","author":[{"given":"K. A.","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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