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The present study was designed to evaluate the behavioural and molecular effects of the anti\u2010depressant imipramine in diabetic rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To this aim, after induction of diabetes by alloxan (150 mg\/kg), Wistar rats were treated with imipramine (30 mg\/kg) once a day for 14 days and then subjected to behavioural tests. BDNF was then assessed in the prefrontal cortex, hippocampus and amygdala.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In diabetic rats treated with saline, we observed an increase in the immobility time, compared with control rats treated with saline. Treatment with imipramine decreased the immobility time in nondiabetic and diabetic rats, compared with both nondiabetic and diabetic rats treated with saline. In the open\u2010field test, it was observed that treatment with imipramine reduced the number of crossings the diabetic rats performed, compared with nondiabetic rats treated with saline. The number of rearings did not alter in any of the groups. Diabetic rats injected with saline did not show altered BDNF levels in the prefrontal cortex, hippocampus or amygdala, but interestingly, the treatment with imipramine in diabetic animals increased BDNF levels in the prefrontal cortex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, this study demonstartes a link between diabetes and depression in rats and that imipramine exerted antidepressant effects in diabetic animals. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.1285","type":"journal-article","created":{"date-parts":[[2011,8,16]],"date-time":"2011-08-16T23:42:27Z","timestamp":1313538147000},"page":"139-144","source":"Crossref","is-referenced-by-count":32,"title":["Imipramine treatment reverses depressive\u2010like behavior in alloxan\u2010diabetic rats"],"prefix":"10.1002","volume":"28","author":[{"given":"Luciane B.","family":"Ceretta","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias and Instituto Nacional de Ci\u00eancia e Tecnologia Translacional em Medicina (INCT\u2010TM), Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade Unidade Acad\u00eamica de Ci\u00eancias da Sa\u00fade, Universidade do Extremo Sul Catarinense  Crici\u00fama SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gislaine 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