{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T14:47:35Z","timestamp":1758120455512},"reference-count":62,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,10,23]],"date-time":"2001-10-23T00:00:00Z","timestamp":1003795200000},"content-version":"vor","delay-in-days":52,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adrenomedullin (AM) is a novel 52 amino acid peptide hormone, originally isolated from human pheochromocytoma. AM acts as a local autocrine and\/or paracrine vasoactive hormone and has vasodilator and blood pressure lowering properties. AM as a vasodilative molecule protects the vascular wall but its exact role is still uncertain. AM is considered to play an important endocrine role in various tissues in maintaining electrolyte and fluid homeostasis. Its plasma concentration in healthy conditions is low. In hypertension, chronic renal failure and congestive heart failure its plasma concentration increases in a parallel manner with the severity of the disease. It is assumed that this peptide plays an important role in physiological and pathological conditions compensating the effects of vasoconstrictive molecules. Investigations have proven that in diabetic angiopathies the levels and production of vasoconstrictive factors and AM are increased, while other relaxing substances such as nitric oxide (NO) are decreased. It is still uncertain whether the increased release of AM is a compensatory mechanism or a coincidental event. Although the precise role of AM in the pathogenesis of diabetic complications is still to be elucidated, the altered concentration of AM in diabetes could indicate a certain interaction between AM induction and vascular function. Hence, the induction of vascular AM can be a new target of therapeutic approach to diabetic complications. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/dmrr.223","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:17:12Z","timestamp":1030310232000},"page":"321-329","source":"Crossref","is-referenced-by-count":10,"title":["Adrenomedullin and diabetes mellitus"],"prefix":"10.1002","volume":"17","author":[{"given":"Eva","family":"Ruzicska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miklos","family":"Toth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Tulassay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniko","family":"Somogyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,10,23]]},"reference":[{"key":"e_1_2_15_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.26.6.869"},{"key":"e_1_2_15_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1996.1780527.x"},{"key":"e_1_2_15_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.14.3.173"},{"key":"e_1_2_15_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1998.t01-15-.x"},{"key":"e_1_2_15_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00357-4"},{"key":"e_1_2_15_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1451"},{"key":"e_1_2_15_8_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2229"},{"key":"e_1_2_15_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1881"},{"key":"e_1_2_15_10_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0910003"},{"key":"e_1_2_15_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2039"},{"key":"e_1_2_15_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(99)00128-X"},{"key":"e_1_2_15_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)80106-1"},{"key":"e_1_2_15_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.5.1750"},{"key":"e_1_2_15_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.24.5.600"},{"key":"e_1_2_15_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1996.tb05977.x"},{"key":"e_1_2_15_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.1.95"},{"key":"e_1_2_15_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.34.5.1147"},{"key":"e_1_2_15_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117573"},{"key":"e_1_2_15_20_2","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.22.61"},{"key":"e_1_2_15_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.5.1214"},{"key":"e_1_2_15_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200000006-00018"},{"key":"e_1_2_15_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.2.216"},{"key":"e_1_2_15_24_2","first-page":"1066","article-title":"PAMP is a novel inhibitor of the tachykinin release in the airway of guinea pigs","volume":"272","author":"Kanazawa H","year":"1997","journal-title":"Am J Physiol"},{"key":"e_1_2_15_25_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.136.9.7649118"},{"key":"e_1_2_15_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00060793-199806000-00009"},{"key":"e_1_2_15_27_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1827"},{"key":"e_1_2_15_28_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2241"},{"key":"e_1_2_15_29_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1148"},{"key":"e_1_2_15_30_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1496"},{"key":"e_1_2_15_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)80143-6"},{"key":"e_1_2_15_32_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.136.5.7720662"},{"key":"e_1_2_15_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.43.25344"},{"key":"e_1_2_15_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/30666"},{"key":"e_1_2_15_35_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2390"},{"key":"e_1_2_15_36_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2497"},{"key":"e_1_2_15_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00358-6"},{"key":"e_1_2_15_38_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.1999.03047.x"},{"key":"e_1_2_15_39_2","unstructured":"LewisLK CharlesCJ SmithCJ et al.Adrenomedullin: biological actions breakdown and radioimmunoassay(Abstract O\u201027). COE International Symposium. The 10th Japan Symposium on ANP National Cardiovascular Center Osaka Japan 1995."},{"key":"e_1_2_15_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(98)00110-7"},{"key":"e_1_2_15_41_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2281.2000.00284.x"},{"key":"e_1_2_15_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.27.3.663"},{"key":"e_1_2_15_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.77.4.660"},{"key":"e_1_2_15_44_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.6.5197"},{"key":"e_1_2_15_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.11.1062"},{"key":"e_1_2_15_46_2","first-page":"A78","article-title":"Ruskoaho, Toth M. Increased cardiac gene expression of adrenomedullin in AII induced cardiac hypertrophy in normal and adrenalectomized rats (presented at the XXth Meeting of the International Society for Heart Research, European Section)","volume":"31","author":"Foldes G","year":"1999","journal-title":"J Mol Cell Cardiol"},{"key":"e_1_2_15_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00122-4"},{"key":"e_1_2_15_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.31.1.505"},{"key":"e_1_2_15_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.5.1146"},{"key":"e_1_2_15_50_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.25.4.790"},{"key":"e_1_2_15_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12998-0"},{"key":"e_1_2_15_52_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.19.2309"},{"key":"e_1_2_15_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)64211-0"},{"key":"e_1_2_15_54_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0664"},{"key":"e_1_2_15_55_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.2.253"},{"key":"e_1_2_15_56_2","first-page":"148","article-title":"Adrenomedullin and proadrenomedullin N\u2010terminal 20 peptide in impaired renal function","volume":"49","author":"Eto T","year":"1996","journal-title":"Kidney Int"},{"key":"e_1_2_15_57_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.6.999"},{"key":"e_1_2_15_58_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.45.241"},{"key":"e_1_2_15_59_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.6.864a"},{"key":"e_1_2_15_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(99)00158-8"},{"key":"e_1_2_15_61_2","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1210\/endo.137.6.8641217","article-title":"Regulation of insulin secretion and blood glucose metabolism by adrenomedullin","volume":"137","author":"Martinez A","year":"1996","journal-title":"Endocrinology"},{"key":"e_1_2_15_62_2","first-page":"A686","article-title":"Adrenomedullin receptor characterization using the selective antagonist adrenomedullin (22\u201052)","volume":"10","author":"Aiyar N","year":"1996","journal-title":"FASEB J"},{"key":"e_1_2_15_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(96)00251-3"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdmrr.223","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T17:06:13Z","timestamp":1700413573000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":62,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["10.1002\/dmrr.223"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.223","archive":["Portico"],"relation":{},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,9]]}}}