{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:06:53Z","timestamp":1761919613809},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T00:00:00Z","timestamp":1357603200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>FTY720, an analogue of sphingosine\u20101\u2010phosphate, has shown potential in the treatment of several autoimmune diseases, such as multiple sclerosis, type 1 diabetes and systemic lupus erythematosus. It prevents development or cure of autoimmune diabetes in animal models. Recently, we reported that FTY720 also prevents development of diabetes in db\/db mice by <jats:italic>\u03b2<\/jats:italic>\u2010cell regeneration <jats:italic>in vivo<\/jats:italic>. This study investigated the effect of FTY720 on apoptosis in <jats:italic>\u03b2<\/jats:italic>\u2010cells in db\/db mice treated with FTY720 16\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six week old female db\/db mice were divided into control and FTY720 groups. FTY720 (10\u2009mg\/kg) was orally administrated daily. Body weights and fasting glucose levels were measured once a week after overnight fasting. After 16\u2009weeks of treatment, oral glucose and insulin tolerance tests were performed, serum insulin levels and insulin contents in pancreas were determined, and then all mice were subjected to physiological and histological analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FTY720\u2010treated mice showed normal fasting glucose levels, improved glucose tolerance with normal insulin sensitivity and restored <jats:italic>\u03b2<\/jats:italic>\u2010cell function to produce and secret insulin. Pancreas histology revealed that FTY720 prevented islet damage and preserved <jats:italic>\u03b2<\/jats:italic>\u2010cell mass by inhibiting apoptosis and increasing <jats:italic>\u03b2<\/jats:italic>\u2010cell survival in pancreatic islets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We concluded that early intervention with FTY720 in db\/db mice can prevent development of diabetes through preserving <jats:italic>\u03b2<\/jats:italic>\u2010cell mass by inhibiting apoptosis and increasing survival of islet <jats:italic>\u03b2<\/jats:italic>\u2010cells. 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