{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:51:05Z","timestamp":1761519065712},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T00:00:00Z","timestamp":1378425600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to compare the metabolic and insulin secretory responses to dexamethasone with the metabolic responses observed at 10\u2009years in normoglycaemic relatives of type 2 diabetic and healthy control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty relatives and 20 matched control subjects were studied twice at 0\u2009year (pre\u2010 and post\u2010dexamethasone) and at 10\u2009years, employing a 75\u2010g oral glucose tolerance test (OGTT), with serial measurements of glucose and insulin, for determination of glucose tolerance and calculations of acute insulin release (\u0394<jats:italic>I<\/jats:italic><jats:sub>30<\/jats:sub>\/\u0394<jats:italic>G<\/jats:italic><jats:sub>30<\/jats:sub>; insulinogenic index) and insulin sensitivity (SI<jats:sub>HOMA<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following dexamethasone, the relatives group developed varying degrees of glucose intolerance, associated with reduced insulin sensitivity and insulinogenic index. By 10\u2009years, fasting glucose and 2\u2010h OGTT glucose were raised in the relatives group, especially in the relatives most metabolically affected by dexamethasone, including a reduced insulinogenic index. Multiple regression analysis of the data in relatives demonstrated that the 2\u2010h OGTT glucose and fasting glucose values at 10\u2009years depended on the 0\u2010year post\u2010dexamethasone 2\u2010h OGTT glucose, post\u2010dexamethasone fasting glucose and post\u2010dexamethasone insulin sensitivity, <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup><jats:sub>adj<\/jats:sub>\u2009=\u200956% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup><jats:sub>adj<\/jats:sub>\u2009=\u200960% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), respectively. No pre\u2010dexamethasone metabolic or insulin secretory responses entered these models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In relatives, fasting and 2\u2010h OGTT glucose concentrations and \u03b2\u2010cell responses to acute dexamethasone\u2010induced insulin resistance are similar to those observed at 10\u2009years, especially in relatives who develop the most disturbed dexamethasone\u2010induced glucose intolerance and impaired acute insulin secretion. The combined 0\u2010year, post\u2010dexamethasone fasting and 2\u2010h OGTT glucose concentrations and insulin resistance, measured as SI<jats:sub>HOMA<\/jats:sub>, are the best predictors in relatives of future dysglycaemia. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.2418","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T11:06:13Z","timestamp":1365505573000},"page":"492-498","source":"Crossref","is-referenced-by-count":2,"title":["The metabolic responses induced by acute dexamethasone predict glucose tolerance and insulin secretion over 10\u2009years in relatives of type 2 diabetic subjects"],"prefix":"10.1002","volume":"29","author":[{"given":"Tina Trier","family":"Durck","sequence":"first","affiliation":[{"name":"Diabetes Research Centre, Department of Endocrinology University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Erik","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre, Department of Endocrinology University of Southern Denmark  Odense 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