{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:25:41Z","timestamp":1791530741425,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T00:00:00Z","timestamp":1415923200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK20542"],"award-info":[{"award-number":["DK20542"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK20579"],"award-info":[{"award-number":["DK20579"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RR00750"],"award-info":[{"award-number":["RR00750"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RR00036"],"award-info":[{"award-number":["RR00036"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000801","name":"Bayer Healthcare","doi-asserted-by":"crossref","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have measured the ability of interventions to affect declining <jats:italic>\u03b2<\/jats:italic>\u2010cell function in screen\u2010detected type 2 diabetes. The Early Diabetes Intervention Programme (ClinicalTrials.gov NCT01470937) was a randomized study based on the hypothesis that improving postprandial glucose excursions with acarbose would slow the progression of fasting hyperglycaemia in screen\u2010detected type 2 diabetes. In the Early Diabetes Intervention Programme, the effect of acarbose plus lifestyle advice on progression of fasting hyperglycaemia over a 5\u2010year period was not greater than that of placebo. However, there was an early glucose\u2010lowering effect of the trial. The objective of the current secondary analysis was to describe <jats:italic>\u03b2<\/jats:italic>\u2010cell function changes in response to glucose lowering.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were overweight adult subjects with screen\u2010detected type 2 diabetes. <jats:italic>\u03b2<\/jats:italic>\u2010cell function was measured using hyperglycaemic clamps and oral glucose tolerance testing. The primary outcome was the change in <jats:italic>\u03b2<\/jats:italic>\u2010cell function from baseline to year 1, the time point where the maximal glucose\u2010lowering effect was seen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, participants exhibited markedly impaired first\u2010phase insulin response. Despite significant reductions in weight, fasting plasma glucose (PG) and 2\u2010h PG, there was no clinically significant improvement in the first\u2010phase insulin response. Late\u2010phase insulin responses declined despite beneficial glycaemic effects of interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Insulin secretion is already severely impaired in early, screen\u2010detected type 2 diabetes. Effective glucose\u2010lowering intervention with acarbose was not sufficient to improve insulin secretion or halt the decline of <jats:italic>\u03b2<\/jats:italic>\u2010cell function. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.2553","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T11:14:44Z","timestamp":1399893284000},"page":"767-776","source":"Crossref","is-referenced-by-count":10,"title":["Profound defects in <i><b>\u03b2<\/b><\/i>\u2010cell function in screen\u2010detected type 2 diabetes are not improved with glucose\u2010lowering treatment in the Early Diabetes Intervention Program (EDIP)"],"prefix":"10.1002","volume":"30","author":[{"given":"Tamara S.","family":"Hannon","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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