{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:17:05Z","timestamp":1787314625722,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T00:00:00Z","timestamp":1409702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The main objective of this study was to estimate the occurrence of diabetic nephropathy in a population\u2010based cohort of patients diagnosed with diabetes as young adults (15\u201334\u00a0years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All 794 patients registered 1987\u20131988 in the Diabetes Incidence Study in Sweden (DISS) were invited to a follow\u2010up study 15\u201319\u00a0years after diagnosis, and 468 (58%) participated. Analysis of islet antibodies was used to classify type of diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After median 17\u00a0years of diabetes, 15% of all patients, 14% T1DM and 25% T2DM, were diagnosed with diabetic nephropathy. Ninety\u2010one percent had microalbuminuria and 8.6% macroalbuminuria. Older age at diagnosis (HR 1.05; 95% CI 1.01\u20131.10 per year) was an independent and a higher BMI at diabetes diagnosis (HR 1.04; 95% CI 1.00\u20131.09 per 1\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), a near\u2010significant predictor of development of diabetic nephropathy. Age at onset of diabetes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041), BMI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012) and HbA1c (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were significant predictors of developing diabetic nephropathy between 9 and 17\u00a0years of diabetes. At 17\u00a0years of diabetes duration, a high HbA1c level (OR 1.06; 95% CI 1.03\u20131.08 per 1\u00a0mmol\/mol increase) and systolic blood pressure (OR 1.08; 95% CI 1.05\u00a01.12 per 1\u00a0mmHg increase) were associated with DN.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with T2DM diagnosed as young adults seem to have an increased risk to develop diabetic nephropathy compared with those with T1DM. Older age and higher BMI at diagnosis of diabetes were risk markers for development of diabetic nephropathy. In addition, poor glycaemic control but not systolic blood pressure at 9\u00a0years of follow\u2010up was a risk marker for later development of diabetic nephropathy. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.2574","type":"journal-article","created":{"date-parts":[[2014,7,5]],"date-time":"2014-07-05T05:24:23Z","timestamp":1404537863000},"page":"138-146","source":"Crossref","is-referenced-by-count":33,"title":["The risk for diabetic nephropathy is low in young adults in a 17\u2010year follow\u2010up from the Diabetes Incidence Study in Sweden (DISS). Older age and higher BMI at diabetes onset can be important risk factors"],"prefix":"10.1002","volume":"31","author":[{"given":"M. K.","family":"Svensson","sequence":"first","affiliation":[{"name":"Department of Medicine Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tyrberg","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Helsingborg Hospital Lund University  Helsingborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Nystr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Epidemiology Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. J.","family":"Arnqvist","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Link\u00f6ping University Hospital  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bolinder","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, and Diabetes Karolinska University Hospital Huddinge, Karolinska Institutet  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"\u00d6stman","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, and Diabetes Karolinska University Hospital Huddinge, Karolinska Institutet  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gudbj\u00f6rnsdottir","sequence":"additional","affiliation":[{"name":"Department of Medicine Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Landin\u2010Olsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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