{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:43:16Z","timestamp":1772120596214,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T00:00:00Z","timestamp":1413590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Key Programs of Science and Technology of Fujian Province","award":["2013Y0037"],"award-info":[{"award-number":["2013Y0037"]}]},{"name":"Medical Innovation Project in Fujian Province","award":["2011-CX-13"],"award-info":[{"award-number":["2011-CX-13"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiovascular disease is prevalent in type 2 diabetics, and microalbuminuria is associated with cardiovascular disease morbidity. We aimed to investigate the potential association between low\u2010grade albuminuria and arterial stiffness in patients with type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2009 and 2013, a retrospective study was performed in 578 patients with type 2 diabetes (339 male patients and 239 female patients) with normal urinary albumin\u2010to\u2010creatinine ratios (ACRs; &lt;30\u2009mg\/g) from Fuzhou, China. Patients were stratified into tertiles based on urinary ACR levels (lowest tertile, urinary ACR\u2009&lt;\u20094.8\u2009mg\/g; highest tertile, urinary ACR\u2009\u2265\u200920.1 mg\/g). Arterial stiffness was measured via brachial\u2010ankle pulse wave velocity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Brachial\u2010ankle pulse wave velocity, age, duration of diabetes, systolic blood pressure and pulse wave velocity progressively increased across all urinary albumin\u2010to\u2010creatinine ratio tertiles (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Patients in the second and the highest tertiles had significantly elevated pulse wave velocity [114.6\u2009mm\/s (95% CI\u2009=\u200936.8\u2013192.4) and 209.4\u2009mm\/s (95% CI\u2009=\u2009131.8\u2013286.9)], <jats:italic>p<\/jats:italic>\u2009=\u20090.004 and 0.000] compared with those in the lowest ACR tertile. The association between ACR and elevated pulse wave velocity still persisted in patients younger than 65\u2009years of age and those with diabetes &lt;10\u2009years, conferring 45 or 51% greater risk of elevated pulse wave velocity (OR\u2009=\u20091.451; 95% CI\u2009=\u20091.119\u20131.881; <jats:italic>p<\/jats:italic>\u2009=\u20090.005 or OR\u2009=\u20091.515; 95% CI\u2009=\u20091.167\u20131.966; <jats:italic>p<\/jats:italic>\u2009=\u20090.0018) with each ACR tertile increment. Each ACR tertile increment conferred 31.7% higher risk of increased pulse wave velocity (OR\u2009=\u20091.317; 95% CI\u2009=\u20091.004\u20131.729; <jats:italic>p<\/jats:italic>\u2009=\u20090.0468).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with type 2 diabetes with urinary albumin excretion in the upper normal range were still at risk for target organ damage. Low\u2010grade albuminuria might be an early marker for the detection of arterial stiffness in patients with type 2 diabetes, especially in younger patients with type 2 diabetes with shorter durations of disease. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.2598","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T05:09:27Z","timestamp":1408511367000},"page":"262-268","source":"Crossref","is-referenced-by-count":15,"title":["Low\u2010grade albuminuria associated with brachial\u2010ankle pulse wave velocity in young adults with type 2 diabetes mellitus in China"],"prefix":"10.1002","volume":"31","author":[{"given":"Lingning","family":"Huang","sequence":"first","affiliation":[{"name":"Endocrinology Department The First Affiliated Hospital of Fujian Medical University  Fuzhou 350005 Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyong","family":"Yang","sequence":"additional","affiliation":[{"name":"Endocrinology Department The First Affiliated Hospital of Fujian Medical University  Fuzhou 350005 Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Endocrinology Department The First Affiliated Hospital of Fujian Medical University  Fuzhou 350005 Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghui","family":"Liu","sequence":"additional","affiliation":[{"name":"Endocrinology Department The First Affiliated Hospital of Fujian Medical University  Fuzhou 350005 Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofang","family":"Yan","sequence":"additional","affiliation":[{"name":"Endocrinology Department The First Affiliated Hospital of Fujian Medical University  Fuzhou 350005 Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunjie","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.168118"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-11-200406010-00035"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.4.421"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000027871.86296.92"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.4.1157"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.8.1093"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834b5627"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.538132"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm130"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000133312.96477.48"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2009.132"},{"key":"e_1_2_7_13_1","first-page":"204","article-title":"Urinary albumin excretion associated with arterial wall stiffness rather than thickness in type 2 diabetic patients","volume":"20","author":"Ishimura E","year":"2007","journal-title":"J Nephrol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.04.011"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.2007.S5"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1024\/0040-5930.63.9.565"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1380"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00752.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-13-37"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi014"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200207000-00018"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01679.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000031732.78052.81"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.538132"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0544"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00752.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004090769"},{"key":"e_1_2_7_28_1","first-page":"204","article-title":"Urinary albumin excretion associated with arterial wall stiffness rather than thickness in type 2 diabetic patients","volume":"20","author":"Ishimura E","year":"2007","journal-title":"J Nephrol"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008121270"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.4250\/jcu.2010.18.4.134"},{"issue":"2","key":"e_1_2_7_31_1","first-page":"204","article-title":"Urinary albumin excretion associated with arterial wall stiffness rather than thickness in type 2 diabetic patients","volume":"12","author":"Ishimura E","year":"2007","journal-title":"J Nephrol"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-9-18"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2005.01688.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.18267"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360867"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-011-0678-4"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdmrr.2598","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.2598","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dmrr.2598","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.2598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T10:07:06Z","timestamp":1694426826000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.2598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,18]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1002\/dmrr.2598"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.2598","archive":["Portico"],"relation":{},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,18]]}}}