{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:40:08Z","timestamp":1788871208596,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T00:00:00Z","timestamp":1417737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Dong-A ST Co., Ltd, Seoul, Republic of Korea"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>DA\u20101229 is a novel, potent and selective dipeptidyl peptidase\u20104 (DPP\u2010IV) inhibitor that is orally bioavailable. We aimed to evaluate the optimal dose, efficacy and safety of DA\u20101229, in Korean subjects with type 2 diabetes mellitus suboptimally controlled with diet and exercise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We enrolled 158 patients (mean age, 53\u00a0years and a mean BMI, 25.6\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). The mean baseline fasting plasma glucose level, HbA1c and duration of diabetes were 8.28\u00a0mmol\/L, 7.6% (60\u00a0mmol\/mol) and 3.9\u00a0years, respectively. After 2 or 6\u00a0weeks of an exercise and diet program followed by 2\u00a0weeks of a placebo period, the subjects were randomized into one of four groups for a 12\u2010week active treatment period: placebo, 2.5, 5 or 10\u00a0mg of DA\u20101229.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All three doses of DA\u20101229 significantly reduced HbA1c from baseline compared to the placebo group (\u22120.09 in the placebo group vs. \u22120.56, \u22120.66 and \u22120.61% in 2.5, 5 and 10\u2010mg groups, respectively) but without any significant differences between the doses. Insulin secretory function, as assessed by homeostasis model assessment \u03b2\u2010cell, the insulinogenic index, 2\u2010h oral glucose tolerance test (OGTT) C\u2010peptide and post\u2010OGTT C\u2010peptide area under the curve (AUC)\n                      <jats:sub>0\u20132h,<\/jats:sub>\n                      significantly improved with DA\u20101229 treatment. The incidence of adverse events was similar between the treatment groups and DA\u20101229 did not affect body weight or induce hypoglycaemic events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      DA\u20101229 monotherapy (5\u00a0mg for 12\u00a0weeks) improved HbA1c, fasting plasma glucose level, OGTT results and \u03b2\u2010cell function. This drug was well tolerated in Korean subjects with type 2 diabetes mellitus. \u00a9 2014 The Authors.\n                      <jats:italic>Diabetes\/Metabolism Research and Reviews<\/jats:italic>\n                      published by John Wiley &amp; Sons, Ltd.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.2613","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T04:39:17Z","timestamp":1414989557000},"page":"295-306","source":"Crossref","is-referenced-by-count":35,"title":["A randomized, double\u2010blind, placebo\u2010controlled, phase II clinical trial to investigate the efficacy and safety of oral DA\u20101229 in patients with type 2 diabetes mellitus who have inadequate glycaemic control with diet and exercise"],"prefix":"10.1002","volume":"31","author":[{"given":"Chang Hee","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol\u2010Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kangbuk Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu\u2010Joeng","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gangdong Kyunghee University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan\u2010Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea University Ansan Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hak\u2010Chul","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University 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