{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:07:28Z","timestamp":1761581248137},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T00:00:00Z","timestamp":1417737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The association of diabetes mellitus and bladder cancer recurrence following radical nephroureterectomies (RNUs) in patients with upper urinary tract urothelial carcinoma (UTUC) was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 1996 and March 2009, 538 patients with UTUC who received RNU and had no previous bladder cancer histories were enrolled. The clinicopathological characteristics were obtained and used for the analysis of metachronous bladder recurrence by using Cox proportional hazard model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The diabetic patients (<jats:italic>N<\/jats:italic>\u2009=\u2009104, 19.3%) were elderly (72 vs 67\u00a0years, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and had more hypertension (56.7 vs 34.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) as compared with non\u2010diabetic patients. There was no significant difference in the rest of clinicopathological characteristics between patient groups. During the median follow\u2010up duration of 51\u00a0months, bladder recurrences were discovered in 47.1 and 33.1% of diabetic and non\u2010diabetic patients with UTUC, respectively. Poorly controlled diabetic patients (HbA<jats:sub>1c<\/jats:sub>\u2009\u2265\u20097.0%) exhibited a shorter duration of bladder cancer recurrence\u2010free survival as compared with those with good glycemic controlled diabetes mellitus and without diabetes mellitus (log\u2010rank test, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and &lt;0.001, respectively). In the multivariate analysis, male gender [hazard ratio (HR)\u2009=\u20091.67, <jats:italic>p<\/jats:italic>\u2009=\u20090.017], ureteral tumour (HR\u2009=\u20091.61, <jats:italic>p<\/jats:italic>\u2009=\u20090.020), end\u2010stage renal disease (HR\u2009=\u20092.09, <jats:italic>p<\/jats:italic>\u2009=\u20090.030) and diabetes mellitus with poor glycemic control (HR\u2009=\u20092.10, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.018) independently predicted bladder recurrence after RNU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Diabetes mellitus with poor glycemic control (HbA<jats:sub>1c<\/jats:sub>\u2009\u2265\u20097.0%) increases the risk of subsequent bladder cancer recurrence. These results underscore the need for intensive glycemic control and close follow\u2010up for diabetic patients. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.2614","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T09:37:30Z","timestamp":1415007450000},"page":"307-314","source":"Crossref","is-referenced-by-count":42,"title":["Diabetes mellitus with poor glycemic control increases bladder cancer recurrence risk in patients with upper urinary tract urothelial carcinoma"],"prefix":"10.1002","volume":"31","author":[{"given":"Yi\u2010Sheng","family":"Tai","sequence":"first","affiliation":[{"name":"Department of Urology National Taiwan University Hospital Yun\u2010Lin Branch  Yun\u2010Lin Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung\u2010Hsin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology National Taiwan University Hospital Yun\u2010Lin Branch  Yun\u2010Lin Taiwan"},{"name":"Department of Urology National Taiwan University Hospital and College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao\u2010Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology National Taiwan University Hospital and College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huai\u2010Chin","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Urology National Taiwan University Hospital and College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho\u2010Mon","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology National Taiwan University Hospital and College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong\u2010Shiau","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Urology National Taiwan University Hospital and College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.48.1.6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000050969"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06519.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.08.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07438.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-011-9915-z"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.1.177"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25641"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2011.02.014"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2013.09.016"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01529-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990315)85:6<1342::AID-CNCR17>3.0.CO;2-B"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119920109"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28013"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP10357.RA"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2011.02845.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0468-0"},{"key":"e_1_2_8_20_1","first-page":"583786","article-title":"Diabetes and risk of cancer","volume":"2013","author":"Habib SL","year":"2013","journal-title":"ISRN Oncol"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-1489"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1068"},{"issue":"24","key":"e_1_2_8_23_1","first-page":"5835","article-title":"Clonal and chronological genetic analysis of multifocal cancers of the bladder and upper urinary tract","volume":"58","author":"Takahashi T","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204671"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01062-8"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113768"},{"issue":"10","key":"e_1_2_8_27_1","first-page":"2630","article-title":"Persistence of carcinogen\u2010altered cell population in rat urothelium which can be promoted to tumors by chronic inflammatory stimulus","volume":"54","author":"Kawai K","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(75)90367-2"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2002.02522.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)63999-7"},{"issue":"21","key":"e_1_2_8_31_1","first-page":"4667","article-title":"Dietary restriction reduces insulin\u2010like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53\u2010deficient mice","volume":"57","author":"Dunn SE","year":"1997","journal-title":"Cancer Res"},{"issue":"23","key":"e_1_2_8_32_1","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1001\/jama.1997.03550230045035","article-title":"Risk of end\u2010stage renal disease in diabetes mellitus: a prospective cohort study of men screened for MRFIT Multiple Risk Factor Intervention Trial","volume":"278","author":"Brancati FL","year":"1997","journal-title":"JAMA"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdmrr.2614","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.2614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dmrr.2614","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.2614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T10:07:10Z","timestamp":1694426830000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.2614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,5]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1002\/dmrr.2614"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.2614","archive":["Portico"],"relation":{},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,5]]}}}