{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:32:30Z","timestamp":1761895950446},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T00:00:00Z","timestamp":1418342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We describe the relationship between dysglycemia and long\u2010term mortality and elucidate the relationship between blood glucose levels during an oral glucose tolerance test (OGTT) and haemoglobin A1 (HbA1) and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 1410 individuals was followed for 33\u00a0years since 1980. Fasting and post\u2010OGTT glucose parameters were used to categorize the cohort according to baseline glycemic status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mortality rate increased from 43% in normoglycemic individuals to 53.3, 61.7, 72.9 and 88.0% in those with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), IFG\/IGT and diabetes, respectively. The highest mortality rate, compared with the normoglycemic category, was observed in individuals with IFG\/IGT and diabetes according to a Cox proportional hazard model (HR\u2009=\u20091.38, 95%CI 1.10\u20131.74 and HR\u2009=\u20092.14, 95%CI 1.70\u20132.70, respectively), followed by individuals with IGT and IFG, but this did not reach statistical significance. We speculate that the IFG group may represent a mixture of individuals en route from normal to the next two categories as well as another cohort whose glucose levels are stably set at the upper reaches of the normal distribution.<\/jats:p><jats:p>Significant differences were found between 1 and 2\u00a0h glucose values (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Fasting, 60 and 120\u00a0min glucose values were positively associated with increasing HbA1 quintiles (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The mean HbA1 was significantly higher in those who died (<jats:italic>p<\/jats:italic>\u2009=\u20090.01). The highest mortality (58.8%) was observed in the upper HbA1 quintile that was also associated with the highest prevalence of the metabolic syndrome (17.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study shows a continuous relationship between the severity of dysglycemia and long\u2010term mortality and should promote the early recognition of prediabetes. The 1\u00a0h post\u2010load glucose level was continuously associated with increasing HbA1 concentrations and may therefore serve as an early marker for abnormalities in glucose tolerance. An elevated 1\u00a0h post\u2010load glucose level may potentially identify at\u2010risk individuals well before the traditional 2\u00a0h glucose value. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.2618","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T18:16:24Z","timestamp":1414520184000},"page":"368-375","source":"Crossref","is-referenced-by-count":21,"title":["Dysglycemia and long\u2010term mortality: observations from the Israel study of glucose intolerance, obesity and hypertension"],"prefix":"10.1002","volume":"31","author":[{"given":"Michael","family":"Bergman","sequence":"first","affiliation":[{"name":"NYU School of Medicine, Department of Medicine, Division of Endocrinology and Metabolism NYU Diabetes and Endocrine Associates  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Chetrit","sequence":"additional","affiliation":[{"name":"Unit for Cardiovascular Epidemiology The Gertner Institute for Epidemiology and Health Policy Research  Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"Roth","sequence":"additional","affiliation":[{"name":"The Feinstein Institute for Medical Research  Manhasset NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Dankner","sequence":"additional","affiliation":[{"name":"Unit for Cardiovascular Epidemiology The Gertner Institute for Epidemiology and Health Policy Research  Tel Hashomer Israel"},{"name":"The Feinstein Institute for Medical Research  Manhasset NY USA"},{"name":"Sackler Faculty of Medicine, School of Public Health, Department of Epidemiology and Preventive Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2002.00835.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-9033"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2373"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2011.02.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.30.7.613"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113761"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00456115"},{"issue":"3","key":"e_1_2_9_9_1","first-page":"375","article-title":"Hyperinsulinemia\u2010\u2010a link between glucose intolerance, obesity, hypertension, dyslipoproteinemia, elevated serum uric acid and internal cation imbalance","author":"Modan M","year":"1987","journal-title":"Diabete Metab"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.28.12.1039"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)90599-0"},{"key":"e_1_2_9_12_1","volume-title":"Lipid and Lipoprotein Analysis","author":"Manual of Laboratory Operations","year":"1974"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0634"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0225"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3971"},{"issue":"2","key":"e_1_2_9_16_1","first-page":"S4","article-title":"Plasma glucose concentration and prediction of future risk of type 2 diabetes","volume":"32","author":"Abdul\u2010Ghani MA","year":"2009","journal-title":"Diabetes Care"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60619-X"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1171"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1443-3"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0438"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2179"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908359"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7277.15"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/met.2011.0032"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.3.397"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.10.1845"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051249"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.6.920"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2631"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdmrr.2618","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.2618","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T14:17:00Z","timestamp":1696601820000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.2618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,12]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1002\/dmrr.2618"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.2618","archive":["Portico"],"relation":{},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,12]]}}}