{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:47:22Z","timestamp":1778626042717,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,1,31]],"date-time":"2002-01-31T00:00:00Z","timestamp":1012435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thiazolidinediones (TZDs) are a recently introduced generation of drugs acting as receptor agonists to reduce insulin resistance and used currently in combination with other hypoglycaemic agents for the treatment of type 2 diabetes. In addition, TZDs possess anti\u2010inflammatory properties that make them of interest for reducing the T\u2010cell inflammation occurring in the islets in type 1 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The action of TZD treatment on diabetes incidence in the non\u2010obese diabetic (NOD) mouse was studied by investigating the effect of rosiglitazone (RGL) (400\u2009mg\/kg body weight by gavage) from 3 weeks of age (soon after weaning) onwards and comparing its effect to that of troglitazone (TGL) given by the same route.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that RGL and TGL both significantly reduced diabetes incidence by &gt;50% in the NOD mouse compared to litter\u2010matched control NOD mice (<jats:italic>p<\/jats:italic>&lt;0.05 and <jats:italic>p<\/jats:italic>&lt;0.01, respectively). However, the withdrawal of TGL from the market due to hepatotoxicity led us to re\u2010analyse our data for toxic liver effects. We found that TGL was more toxic to mice than RGL (causing ten deaths as compared with one death).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RGL reduces diabetes incidence in the NOD mouse model of type 1 diabetes. This may be an effect resulting from its action as on inhibitor of pro\u2010inflammatory genes such as cytokines and metabolic proteases. Its use may be considered for trials designed to protect beta\u2010cell function in humans, especially in patients with latent autoimmune diabetes of adults (LADA) and also for disease prevention. 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