{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:22:54Z","timestamp":1764174174203},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T00:00:00Z","timestamp":1434412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study assesses the autonomic function of patients who have regained awareness of hypoglycaemia following islet cell or whole pancreas transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five patients with type 1 diabetes and either islet cell (four patients) or whole pancreas (one patient) transplant were assessed. These patients were age\u2010matched and gender\u2010matched to five patients with type 1 diabetes without transplant and preserved hypoglycaemia awareness and five healthy control participants without diabetes. All participants underwent (i) a battery of five cardiovascular autonomic function tests, (ii) quantitative sudomotor axonal reflex testing, and (iii) sympathetic skin response testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total recorded hypoglycaemia episodes per month fell from 76 pre\u2010transplant to 13 at 0\u2010 to 3\u2010month post\u2010transplant (83% reduction). The percentage of hypoglycaemia episodes that patients were unaware of decreased from 97 to 69% at 0\u20133\u00a0months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, Fisher's exact test) and to 20% after 12\u00a0months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001, Fisher's exact test). This amelioration was maintained at the time of testing (mean time: 4.1\u00a0years later, range: 2\u20136\u00a0years). Presence of significant autonomic neuropathy was seen in all five transplanted patients (at least 2\/3 above modalities abnormal) but in only one of the patients with diabetes without transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The long\u2010term maintenance of hypoglycaemia awareness that returns after islet cell\/pancreas transplantation in patients with diabetes is not prevented by significant autonomic neuropathy and is better accounted for by other factors such as reversal of hypoglycaemia\u2010associated autonomic failure. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.2652","type":"journal-article","created":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T01:03:04Z","timestamp":1428714184000},"page":"646-650","source":"Crossref","is-referenced-by-count":10,"title":["Assessment of the relationship between hypoglycaemia awareness and autonomic function following islet cell\/pancreas transplantation"],"prefix":"10.1002","volume":"31","author":[{"given":"Jordan T.","family":"Kamel","sequence":"first","affiliation":[{"name":"Centre for Clinical Neurosciences and Neurological Research St. Vincent's Hospital Melbourne  Victoria Australia"},{"name":"Department of Medicine University of Melbourne  Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Nephrology St. Vincent's Hospital Melbourne  Victoria Australia"},{"name":"On behalf of the Australian Islet Transplant Consortium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Howe","sequence":"additional","affiliation":[{"name":"Endocrinology and Diabetes St. Vincent's Hospital Melbourne  Victoria Australia"},{"name":"On behalf of the Australian Islet Transplant Consortium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Cook","sequence":"additional","affiliation":[{"name":"Centre for Clinical Neurosciences and Neurological Research St. Vincent's Hospital Melbourne  Victoria Australia"},{"name":"Department of Medicine University of Melbourne  Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn M.","family":"Ward","sequence":"additional","affiliation":[{"name":"Endocrinology and Diabetes St. Vincent's Hospital Melbourne  Victoria Australia"},{"name":"On behalf of the Australian Islet Transplant Consortium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie J.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Centre for Clinical Neurosciences and Neurological Research St. Vincent's Hospital Melbourne  Victoria Australia"},{"name":"Department of Medicine University of Melbourne  Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050585"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.301.6755.783"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-96-4-459"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0741"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.4.955"},{"key":"e_1_2_10_7_1","volume-title":"Clinical Autonomic Disorders","author":"Low PA","year":"2008"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.285.6346.916"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420509"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.41.8.946"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1215228"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2492"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2426"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3120-9"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199807270-00017"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdmrr.2652","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.2652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T18:33:48Z","timestamp":1696617228000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.2652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,16]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1002\/dmrr.2652"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.2652","archive":["Portico"],"relation":{},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,16]]}}}