{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:49:56Z","timestamp":1790174996024,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T00:00:00Z","timestamp":1434412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81100590"],"award-info":[{"award-number":["81100590"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study is to compare the efficacy and safety of once\u2010daily insulin glargine plus gliclazide modified release combination therapy <jats:italic>versus<\/jats:italic> twice\u2010daily premixed insulin monotherapy in Chinese type 2 diabetic patients insufficiently controlled by oral antidiabetic agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a 12\u2010week, multicenter, randomized, parallel\u2010group clinical trial, patients with poor glycaemic control (fasting plasma glucose\u2009\u2265\u20097.0\u00a0mmol\/L and 7.5%\u2009&lt;\u2009haemoglobin A<jats:sub>1c<\/jats:sub>\u2009\u2264\u200910%) on oral antidiabetic drugs were randomized to the treatment groups for combination therapy (<jats:italic>n<\/jats:italic>\u2009=\u200952) or monotherapy (<jats:italic>n<\/jats:italic>\u2009=\u200953). Continuous glucose monitoring was carried out over two 72\u2010h periods, at the beginning and the end of the study, and the data were used to calculate the 24\u2010h mean blood glucose, mean amplitude of glycaemic excursions, standard deviation of blood glucose, and the mean of daily differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean haemoglobin A<jats:sub>1c<\/jats:sub> decrease from baseline to study end was significant for both treatment groups (combination therapy: \u22121.23\u2009\u00b1\u20090.92%; insulin monotherapy: \u22121.02\u2009\u00b1\u20091.04%); moreover, the combination therapy group showed a significantly more robust haemoglobin A<jats:sub>1c<\/jats:sub> decrease (<jats:italic>p<\/jats:italic>\u2009=\u20090.0308). Both therapies significantly reduced the 24\u2010h mean blood glucose (both, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), but neither produced a significant effect on glycaemic variability, calculated as mean amplitude of glycaemic excursions, standard deviation of blood glucose, and mean of daily differences. In addition, the effects on rates of hypoglycaemic episodes were similar between the two therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chinese patients with type 2 diabetes inadequately controlled with oral antidiabetic agents attained greater benefit from once\u2010daily insulin glargine plus gliclazide modified release regimen than from a twice\u2010daily premixed insulin regimen. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.2661","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T14:28:58Z","timestamp":1431008938000},"page":"725-733","source":"Crossref","is-referenced-by-count":15,"title":["Glargine insulin\/gliclazide MR combination therapy is more effective than premixed insulin monotherapy in Chinese patients with type 2 diabetes inadequately controlled on oral antidiabetic drugs"],"prefix":"10.1002","volume":"31","author":[{"given":"Jian","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenping","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huazhang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Guangdong General Hospital  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muxun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Tongji Hospital Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoming","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Beijing Hospital of Ministry of Public Health  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Second Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 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