{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T05:47:13Z","timestamp":1695880033707},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T00:00:00Z","timestamp":1439856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The metabolic syndrome (MetS) predicts cardiovascular risk and incident type 2 diabetes mellitus. The presence of a MetS is defined by the clustering of \u22653 out of 5 cardiometabolic criteria (<jats:italic>hyperglycemia<\/jats:italic>; <jats:italic>hypertension<\/jats:italic>; <jats:italic>enlarged waist<\/jats:italic>; <jats:italic>low high\u2010density lipoprotein\u2010cholesterol<\/jats:italic>; and <jats:italic>hypertriglyceridemia<\/jats:italic>), each of which is connected with insulin resistance. It is not known whether the severity of MetS, ranked from the sextet of scores range [0\/5 to 5\/5], is linearly related to reduced insulin sensitivity (IS) and\/or lesser hyperbolic product across the glycemic spectrum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>A total of 839 adults (54 normoglycemic; 785 with abnormal glucose homeostasis, among whom 711 type 2 diabetes mellitus) had insulin sensitivity assessed together with their cardiometabolic phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant gradient according to interval\u2010scale MetS score in insulinemia; body mass index; (visceral) fat; hepatic steatosis; and macroangiopathy. There was an inverse linear relationship between increasing MetS scores and decreased insulin sensitivity, allowing to define an insulin resistance\u2010predicting linear equation: IS (%)\u2009=\u2009[\u221215.1\u2009\u00d7\u2009MetS score]\u2009+\u2009109.4 (R<jats:sup>2<\/jats:sup>\u2009=\u20090.221). For each MetS category, mean IS values did not significantly differ between groups of patients across the glycemic spectrum. The hyperbolic product (<jats:italic><jats:bold>\u03b2<\/jats:bold><\/jats:italic>\u2010cell function\u2009\u00d7\u2009IS) and\/or its loss rate were inversely related to MetS severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Insulin sensitivity is linearly and inversely related to MetS severity across the 6 scores. This novel way to exploit information intrinsic to the MetS criteria provides an easy and low cost means to quantify insulin sensitivity across the glycemic spectrum. Moreover, a higher MetS score is associated with lesser residual insulin secretion, and faster B\u2010cell function loss. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.2675","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T08:22:52Z","timestamp":1435306972000},"page":"87-94","source":"Crossref","is-referenced-by-count":7,"title":["How to transform a metabolic syndrome score into an insulin sensitivity value?"],"prefix":"10.1002","volume":"32","author":[{"given":"Michel P.","family":"Hermans","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Nutrition Cliniques universitaires St\u2010Luc and Institut de Recherche Exp\u00e9rimentale et Clinique (IREC), Universit\u00e9 catholique de Louvain  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evariste","family":"Bouenizabila","sequence":"additional","affiliation":[{"name":"Service des Maladies M\u00e9taboliques et Endocriniennes Centre Hospitalier et Universitaire de Brazzaville  Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie A.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Cardiology Cliniques universitaires St\u2010Luc and P\u00f4le de Recherche Cardiovasculaire, Institut de Recherche Exp\u00e9rimentale et Clinique (IREC), Universit\u00e9 catholique de Louvain  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel F.","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Division of Cardiology Cliniques universitaires St\u2010Luc and P\u00f4le de Recherche Cardiovasculaire, Institut de Recherche Exp\u00e9rimentale et Clinique (IREC), Universit\u00e9 catholique de Louvain  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400953"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.106.25.3143"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2003.01068.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67402-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.169404"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.11.046"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl524"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3132\/dvdr.2008.016"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0423"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJR.0b013e32832955fc"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2008.02.004"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-9-88"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-11-132"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2387"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051215"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.9.1779"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3132\/dvdr.2007.019"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.1.201"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.1873"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdmrr.2675","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.2675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T20:37:34Z","timestamp":1695760654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.2675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,18]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1002\/dmrr.2675"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.2675","archive":["Portico"],"relation":{},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,18]]}}}