{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:58:07Z","timestamp":1770415087300,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Danish Agency for Science","award":["09-067009"],"award-info":[{"award-number":["09-067009"]}]},{"name":"Danish Agency for Science","award":["09-075724"],"award-info":[{"award-number":["09-075724"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We investigated whether parental history of type 2 diabetes mellitus (T2D) is associated with age, lifestyle, anthropometric factors, and clinical severity at the time of T2D diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross\u2010sectional study based on the Danish Centre for Strategic Research in Type 2 Diabetes cohort. We examined the prevalence ratios (PR) of demographic, lifestyle, anthropometric, and clinical factors according to parental history, using Poisson regression adjusting for age and gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2825 T2D patients, 34% (<jats:italic>n<\/jats:italic>\u2009=\u2009964) had a parental history of T2D. Parental history was associated with younger age at diagnosis [adjusted (a)PR 1.66, 95% confidence interval: 1.19, 2.31) for age &lt;40\u00a0years; aPR 1.36 (95% confidence interval: 1.24, 1.48) for ages 40\u201359\u00a0years] and with higher baseline fasting plasma glucose [\u22657.5\u00a0mmol\/L, aPR 1.47 (95% confidence interval: 1.20, 1.80)], and also tended to be associated with lower beta cell function. In contrast, patients both with and without a parental history had similar occurrence of central obesity [91% <jats:italic>vs.<\/jats:italic> 91%], weight gain \u226530\u00a0kg since age 20 [52% <jats:italic>vs.<\/jats:italic> 53%], and lack of regular physical activity [60% <jats:italic>vs.<\/jats:italic> 58%]. Presence of diabetes complications or comorbidities at T2D diagnosis was not associated with parental history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The lack of an association between parental history and adverse lifestyle factors indicates that T2D patients do not inherit a particular propensity for overeating or inactivity, whereas patients with a parental history may have more severe pancreatic beta cell dysfunction at diagnosis. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.2721","type":"journal-article","created":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T20:28:43Z","timestamp":1443299323000},"page":"308-315","source":"Crossref","is-referenced-by-count":13,"title":["Association of parental history of type 2 diabetes with age, lifestyle, anthropometric factors, and clinical severity at type 2 diabetes diagnosis: results from the DD2 study"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6706-6336","authenticated-orcid":false,"given":"Elisabeth","family":"Svensson","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Institute of Clinical Medicine, Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klara","family":"Berencsi","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Institute of Clinical Medicine, Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Sander","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Institute of Clinical Medicine, Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Mor","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Institute of Clinical Medicine, Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen","family":"Rungby","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Aarhus  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens Steen","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre Department of Endocrinology, Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"Friborg","sequence":"additional","affiliation":[{"name":"Department of Endocrinology M Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Brandslund","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Lillebaelt Hospital  Vejle Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens Sandahl","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Endocrinology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Vaag","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Rigshospitalet and Copenhagen University  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Beck\u2010Nielsen","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre Department of Endocrinology, Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik Toft","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Institute of Clinical Medicine, Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reimar Wernich","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Institute of Clinical Medicine, Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2715-x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0947"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0720"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.12.2201"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.04.002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-8902.2004.00330.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0147"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0618"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2012.03.014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1586"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6823-9-12"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2000.00330.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S30838"},{"issue":"4","key":"e_1_2_7_15_1","first-page":"441","article-title":"The Danish Civil Registration System. 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