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The goal of any wound regimen should be to optimize wound healing by combining basic wound care modalities including debridement, off\u2010loading, and infection control with the addition of advanced therapies when necessary. This review takes a closer look at current uses of negative pressure wound therapy, bioengineered alternative tissues, and amniotic membrane products. While robust literature may be lacking, current wound care advances are showing great promise in wound healing. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/dmrr.2747","type":"journal-article","created":{"date-parts":[[2015,10,10]],"date-time":"2015-10-10T03:30:41Z","timestamp":1444447841000},"page":"268-274","source":"Crossref","is-referenced-by-count":34,"title":["What's new in wound treatment: a critical appraisal"],"prefix":"10.1002","volume":"32","author":[{"given":"Caitlin S.","family":"Garwood","sequence":"first","affiliation":[{"name":"Diabetic Limb Salvage Fellow MedStar Georgetown University Hospital  3800 Reservoir Rd NW, Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Georgetown University School of Medicine  3800 Reservoir Rd NW, Washington DC USA"},{"name":"MedStar Washington Hospital Center Podiatric Residency  3800 Reservoir Rd NW, Washington DC USA"},{"name":"Center for Wound Healing and Hyperbaric Medicine MedStar Georgetown University Hospital  3800 Reservoir Rd NW, Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181fca244"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2012.04.008"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00485.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2011.20.6.284"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.06.006"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2012.00836.x"},{"key":"e_1_2_5_8_1","first-page":"1","article-title":"Peak foot pressures influence the healing time of diabetic foot ulcers treated with total contact casts","volume":"35","author":"Armstrong DG","year":"1998","journal-title":"J Rehabil Res Dev"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.3.551"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182024864"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2386"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpm.2012.04.005"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-92-9-479"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(02)00191-3"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpm.2008.05.006"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199904000-00011"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpm.2008.05.009"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200308000-00003"},{"issue":"9","key":"e_1_2_5_19_1","first-page":"488","article-title":"Vacuum sealing as treatment of soft tissue damage in open fractures","volume":"96","author":"Fleischmann W","year":"1993","journal-title":"Unfallchirurg"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000225450.12593.12"},{"key":"e_1_2_5_21_1","first-page":"44S","article-title":"The economic value of negative pressure wound therapy","volume":"51","author":"Niezgoda JA","year":"2005","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_5_22_1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/01.ASW.0000305451.71811.d5","article-title":"Early intervention of negative pressure wound therapy using vacuum\u2010assisted closure in trauma patients: impact on hospital length of stay and cost","volume":"22","author":"Kaplan M","year":"2009","journal-title":"Adv Skin Wound Care"},{"key":"e_1_2_5_23_1","doi-asserted-by":"crossref","unstructured":"GameFL ApelqvistJ AttingerCE et al.IWGDF Guidance on use of interventions to enhance the healing of chronic ulcers of the foot in diabetes. 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