{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T14:10:52Z","timestamp":1771596652748,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,2,7]],"date-time":"2016-02-07T00:00:00Z","timestamp":1454803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"REMD Therapeutics Inc"},{"name":"Synalpha Therapeutics LLC"},{"name":"Amylin Pharmaceuticals Inc"},{"name":"Veteran's Administration merit grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Although insulin monotherapy prevents death from ketoacidosis, it does not prevent either the hyperglycemic surges or the hypoglycemic plunges of glucose levels that plague the majority of patients with type 1 diabetes. However, significant improvements have occurred with the combination of continuous insulin delivery matched by continuous glucose monitoring, but the technology is not available for all patients, requires extensive education, is expensive and moreover, while much better than standard care, it almost never reduces haemoglobin A<jats:sub>1c<\/jats:sub> (HbA<jats:sub>1c<\/jats:sub>) to below 6%. This may indicate that an improved diabetes therapy involving antagonism of glucagon action will for the first time control glucose levels to normal and eradicate the long\u2010term complications of diabetes. Although one can never predict that results in animals will be reproduced in humans, the available evidence suggests that patients with type 1 and type 2 diabetes may expect far superior control of the metabolic abnormalities without the need for significant monitoring of glucose, a very important but expensive part of any insulin regimen.<\/jats:p>","DOI":"10.1002\/dmrr.2773","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T04:02:45Z","timestamp":1451966565000},"page":"660-665","source":"Crossref","is-referenced-by-count":23,"title":["Glucagon therapeutics: Dawn of a new era for diabetes care"],"prefix":"10.1002","volume":"32","author":[{"given":"Jaime A.","family":"Davidson","sequence":"first","affiliation":[{"name":"Touchstone Diabetes Centre, Department of Internal Medicine University of Texas Southwestern Medical Centre  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William L.","family":"Holland","sequence":"additional","affiliation":[{"name":"Touchstone Diabetes Centre, Department of Internal Medicine University of Texas Southwestern Medical Centre  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Texas Southwestern Medical Centre  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"May\u2010yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Touchstone Diabetes Centre, Department of Internal Medicine University of Texas Southwestern Medical Centre  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Touchstone Diabetes Centre, Department of Internal Medicine University of Texas Southwestern Medical Centre  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Yu","sequence":"additional","affiliation":[{"name":"Touchstone Diabetes Centre, Department of Internal Medicine University of Texas Southwestern Medical Centre  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara K.","family":"McCorkle","sequence":"additional","affiliation":[{"name":"VA North Texas Health Care System  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp E.","family":"Scherer","sequence":"additional","affiliation":[{"name":"Touchstone Diabetes Centre, Department of Internal Medicine University of Texas Southwestern Medical Centre  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger H.","family":"Unger","sequence":"additional","affiliation":[{"name":"Touchstone Diabetes Centre, Department of Internal Medicine University of Texas Southwestern Medical Centre  Dallas TX USA"},{"name":"VA North Texas Health Care System  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052187"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0653"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2148"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006639107"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.31.10.883"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111658"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10799899209066022"},{"issue":"3","key":"e_1_2_5_9_1","first-page":"252","article-title":"Insulin\u2013glucagon ratio","volume":"8","author":"Unger RH","year":"1972","journal-title":"Isr J Med Sci"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.25.2.136"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(10)70002-1"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.27.4.411"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909422107"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1424934112"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.20.12.785"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0426"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1631"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806993105"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-1878-0"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.47"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-014-0555-4"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197808312990901"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.19.5.302"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.4.523"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0266"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdmrr.2773","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.2773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T03:22:24Z","timestamp":1696562544000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.2773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,7]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1002\/dmrr.2773"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.2773","archive":["Portico"],"relation":{},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,7]]}}}