{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T02:37:27Z","timestamp":1780713447474,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T00:00:00Z","timestamp":1461542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Abnormalities of fibroblast growth factor\u201023 (FGF\u201023) plasma levels predict adverse outcomes in patients with coronary artery disease. However, FGF\u201023 has a different behaviour in the presence of type 2 diabetes mellitus (T2D). We explored whether the presence of T2D affects the predictive power of FGF\u201023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 704 patients with stable coronary artery disease, FGF\u201023, calcidiol, parathormone (PTH) and phosphate plasma levels were prospectively assessed. The primary outcome was the development of acute ischemic events (acute coronary syndrome, stroke or transient ischemic attack), heart failure or death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred seventy\u2010three (24.6%) patients had T2D, without differences in age, sex or estimated glomerular filtration rate as compared with non\u2010diabetic patients. Serum PTH was lower and phosphate higher in T2D than in non\u2010diabetic patients, without differences in FGF\u201023 or calcidiol levels.<\/jats:p><jats:p>During follow\u2010up (2.15\u2009\u00b1\u20090.99\u00a0years), 26 (15.2%) T2D and 51 (9.6%) non\u2010diabetic patients developed the outcome (<jats:italic>p<\/jats:italic>\u2009=\u20090.048). T2D patients who developed the outcome had higher FGF\u201023 [112.0 (59.9, 167.6) <jats:italic>vs<\/jats:italic> 68.9 (54.2, 93.0) RU\/mL; <jats:italic>p<\/jats:italic>\u2009=\u20090.002], PTH [71.3 (47.3, 106.6) <jats:italic>vs<\/jats:italic> 51.9 (40.8, 66.2) pg\/mL; <jats:italic>p<\/jats:italic>\u2009=\u20090.004) and phosphate (3.53\u2009\u00b1\u20090.71 <jats:italic>vs<\/jats:italic> 3.25\u2009\u00b1\u20090.50\u00a0mg\/dL; <jats:italic>p<\/jats:italic>\u2009=\u20090.017) levels than T2D subjects who remained stable. These differences were not significant in non\u2010diabetic patients.<\/jats:p><jats:p>By multivariable Cox proportional hazard model, FGF\u201023 predicted independently the outcome in T2D patients [hazard ratio\u2009=\u20091.277; 95% CI (1.132, 1.442)] but not in those without T2D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FGF\u201023 plasma levels predict adverse cardiovascular outcomes in coronary artery disease patients who have T2D but not in those without T2D. This finding should be confirmed in larger studies. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.2787","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T13:13:13Z","timestamp":1455801193000},"page":"685-693","source":"Crossref","is-referenced-by-count":36,"title":["Circulating fibroblast growth factor\u201023 plasma levels predict adverse cardiovascular outcomes in patients with diabetes mellitus with coronary artery disease"],"prefix":"10.1002","volume":"32","author":[{"given":"Jos\u00e9","family":"Tu\u00f1\u00f3n","sequence":"first","affiliation":[{"name":"IIS\u2010Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid Spain"},{"name":"Aut\u00f3noma University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Fern\u00e1ndez\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"IIS\u2010Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid 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