{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:10:51Z","timestamp":1740103851533,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T00:00:00Z","timestamp":1461196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Clinical and Translational Science Award","award":["UL1RR024134"],"award-info":[{"award-number":["UL1RR024134"]}]},{"name":"Diabetes and Endocrine Research Center Award","award":["P20-DK 019525","K24-HL107643"],"award-info":[{"award-number":["P20-DK 019525","K24-HL107643"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We investigated the association of electrocardiographic (ECG) abnormalities with markers of insulin resistance and pancreatic beta\u2010cell dysfunction in a cross\u2010sectional study of type 2 diabetes patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electrocardiographic criteria were evaluated in the Penn Diabetes Heart Study participants (<jats:italic>n<\/jats:italic>\u2009=\u20091671; 64% male; 61% Caucasian), including a sub\u2010sample (<jats:italic>n<\/jats:italic>\u2009=\u2009710) that underwent oral glucose tolerance testing. The Matsuda Insulin Sensitivity Index and homeostasis model assessment of insulin resistance (HOMA\u2010IR) estimated insulin sensitivity; Insulinogenic Index and homeostasis model assessment of beta\u2010cell function assessed beta\u2010cell function. Multivariable regression modelling was used to analyse associations of ECG changes with these indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In unadjusted analyses, subjects in the highest quartile of Matsuda index had the lowest prevalence of Q\u2010waves (6.3% <jats:italic>versus<\/jats:italic> 15.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.005). In adjusted models, an inverse association was seen between Q\u2010waves and log Matsuda index [one standard deviation increase; OR\u2009=\u20090.59 (95% CI 0.43\u20100.87 p\u2009=\u20090.001)]. In the full Penn Diabetes Heart Study, there was a direct association between Q\u2010waves and HOMA\u2010IR [one standard deviation increase; OR\u2009=\u20091.43 (95% CI 1.13\u20131.81, <jats:italic>p<\/jats:italic>\u2009=\u20090.003)]. In adjusted models, left ventricular hypertrophy also was inversely associated with Matsuda index and directly with HOMA\u2010IR. Higher Insulinogenic Index scores were associated with a lower prevalence of nonspecific ST changes [OR\u2009=\u20090.78 (95% CI 0.62\u20130.98, <jats:italic>p<\/jats:italic>\u2009=\u20090.032)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In type 2 diabetic patients, both oral glucose tolerance testing\u2010derived and HOMA\u2010derived measures of insulin resistance were associated with pathologic Q\u2010waves and left ventricular hypertrophy on ECGs. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.2794","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T23:26:04Z","timestamp":1455837964000},"page":"736-744","source":"Crossref","is-referenced-by-count":4,"title":["Selective association of electrocardiographic abnormalities with insulin sensitivity and beta\u2010cell function in type 2 diabetes mellitus: a cross\u2010sectional analysis"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7155-3484","authenticated-orcid":false,"given":"Anish B.","family":"Bhatt","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Texas South Western  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire K.","family":"Mulvey","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California  San Francisco CA 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